Stanford Cardinal vs Virginia Cavaliers Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: Stanford Cardinal vs Virginia Cavaliers

Date: Saturday, September 20, 2025

Location: Scott Stadium in Charlottesville, VA

TV: ACC Network

Odds/Point Spread: Cavaliers (-15.0)

Total/Over-Under: 49

The Virginia Cavaliers (2-1) welcome the Stanford Cardinal (0-2) at Scott Stadium on Saturday, September 20, 2025. Stanford opens as 15.0-point dogs from Vegas oddsmakers. The total is 49.

The Stanford Cardinal come into this game with a record of 0-2 for this year. In their last matchup, the Cardinal played against the Boston College Eagles and earned the victory with a final of 30-20. Against the rush, the Cardinal conceded 56 yds on 23 attempts, which averages out to 2.4 yds per rush surrendered. Stanford relinquished 30 completions on 44 attempts for a total of 333 yards, and a completion percentage of 68.2%. At the end of the game, they tallied 59 plays which gave them a total of 399 yds. The Stanford Cardinal ran the ball a total of 37 different times and accrued 213 yards, which is an average of 5.8 yds per attempt.

The Cardinal have earned 846 total yards for the year. With reference to scoring, Stanford has compiled 1 touchdown through the air and 2 touchdowns on the ground. They have turned the football over 4 different times. Stanford has accounted for 48 1st downs as an offense, and they have been flagged for 17 infractions for 145 yards. As a team they have an average of 136.3 yards via the ground game giving them a rank of 92nd in the nation. When talking about scoring points, the Stanford Cardinal are averaging 17.7 points per contest.

When talking about passing yards, the Cardinal have given up 718 yds which puts them in 104th in the country. They have conceded 239.3 yards per contest via the pass as well as allowing a completion percentage of 66.8%. For the season, they have allowed 342.3 yards/game ranking them 75th in college football. They have yielded 3 touchdowns by air as well as 3 touchdowns running the ball. They are giving up 3.5 yards per rush on the ground and 103.0 rushing yards per game so far this season. Overall, they have allowed 309 yards on the ground through 3 outings. The Cardinal rank 76th in Division 1 in terms of team defense, giving up 23.3 points per contest.

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The Cavaliers step onto the field holding a record of 2-1 this season. In their last game, the Cavaliers took home the win by a final score of 55-16 when they played the William & Mary Tribe. Virginia relinquished 24 running attempts for 59 yds (2.5 yards per carry). The Cavaliers secondary allowed a completion rate of 52.0%, relinquishing 204 yds on 13 out of 25 passing. The Cavaliers finished the game with a total of 700 yards and they ran 87 plays (8.0 yards per play). Virginia rushed the football for 7.3 yds per carry, finishing with 379 yds on 52 carries.

The Virginia Cavaliers maintain an average of 556.0 yards/contest, which ranks them 8th in Division 1. The Virginia offense has compiled 105 yds of penalties on 15 infractions, which is good for 80th in the country in terms of helping out the other team. They average 266.7 yards per game via the rush and have rushed for 800 yards for the season. They have thrown 2 picks and they have been able to obtain 77 first downs. When it comes to how much they score, the Cavaliers are ranking 18th in the country averaging 44.7 PPG. Over the course of the season to this point, the Cavaliers have earned 868 yards through the air along with an average of 289.3 passing yards per game, ranking them 25th in the nation.

The Cavaliers are giving up 19.3 points per game, which has them ranked 60th in D-1. Virginia has surrendered a total of 366 yards rushing (122.0 yards per contest) and 6 touchdowns on the ground for the year. They have conceded 2 touchdowns via the pass and 189.0 yards/game, ranking them 50th in Division 1. The Cavaliers defense has taken the field for 174 plays, which has them ranked 32nd in college football. They have compiled 2 fumbles and 1 interception on the campaign. Over the course of the season, they have conceded 58 points.

Who will win tonight's Cardinal/Cavaliers college football game against the spread?

Josh's Pick: Take the Cavaliers -15.0

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