Syracuse Orange vs Notre Dame Fighting Irish Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Syracuse Orange vs Notre Dame Fighting Irish

Date: Saturday, November 22, 2025

Location: Notre Dame Stadium in Notre Dame, IN

TV: NBC Peacock

Odds/Point Spread: Fighting Irish (-35.0)

Total/Over-Under: 50.5

Notre Dame Stadium is the site where the Notre Dame Fighting Irish (8-2) will play the Syracuse Orange (3-7) on Saturday, November 22, 2025. Notre Dame opens this contest as 35.0-point favorites from oddsmakers. The over/under is 50.5.

The Syracuse Orange head into this matchup 3-7 for this season. In their last matchup, the Orange took the field against the Miami Hurricanes and went home with a loss by a final score of 38-10. In the game, they tallied 71 plays which gave them a total of 285 yards. The Syracuse Orange ended up rushing 43 different times and accumulated 161 yards, which came out to an average of 3.7 yards per attempt. Against the run, the Orange conceded 124 yds on 32 attempts, which averages out to 3.9 yards per run allowed. Syracuse allowed 19 completions on 25 attempts for 261 yds, and a completion percentage of 76.0%.

The Orange have tallied 3,624 total yards for this campaign. When it comes to distribution of touchdowns, Syracuse has amassed 17 touchdowns through the air and 10 rushing touchdowns. They have turned the ball over 20 different times. Syracuse has compiled 203 1st downs as a unit, and they have been hurt by 61 infractions for 542 yards. Offensively they average 117.7 yards in the run game which ranks them 113th in Division 1. When talking about getting in the endzone, the Syracuse Orange hold an average of 22.3 points per contest.

Regarding passing yards, the Orange have given up 2,670 yards which has them sitting in 121st in Division 1. They have yielded 267.0 yards per contest through the air and allowed a completion percentage of 66.3%. In total, they are allowing 430.4 yards/outing which ranks them 125th in the country. They have conceded 22 touchdowns by air and 14 touchdowns via the ground game. They are allowing 4.7 yards per running attempt and 163.4 rushing yards per game for the year. During this campaign, they have conceded 1,634 rushing yards through 10 outings. The Orange sit in 117th in the country in terms of team defense, giving up 31.5 PPG.

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The Fighting Irish head into this game 8-2 this season. When they last stepped on the gridiron, the Fighting Irish took home the win by a final score of 37-15 against the Pittsburgh Panthers. Notre Dame gave up 45 attempts on the ground for 206 yds (4.6 yds per rush). The Fighting Irish secondary allowed a completion rate of 30.0%, relinquishing 22 yards on 3 out of 10 through the air. The Fighting Irish finished the contest with a total of 387 yds on 68 plays (5.7 yards per play). Notre Dame rushed the ball for 4.9 yards per tote, finishing with 175 yards on 36 attempts.

When it comes to the points being put on the board, the Fighting Irish rank 8th in college football by tallying 38.5 PPG. The Notre Dame Fighting Irish average 458.2 yards per game, which is good for 18th in Division 1. The Notre Dame offense has accrued 532 yds of penalties on 58 infractions, which ranks 89th in college football in terms of making mistakes. They have tossed 6 interceptions while losing 4 fumbles and they have recorded 231 first downs. During the season so far, the Fighting Irish currently sit at 2,657 passing yards not to mention an average of 265.7 passing yards per game, which ranks 30th in the nation. They have an average of 192.5 yards per game on the ground and have run for 1,925 yards overall.

The Fighting Irish are surrendering 18.4 PPG, ranking them 18th in D-1. Notre Dame has yielded a total of 993 rushing yards (99.3 yards per outing) and 7 touchdowns via the rush for the campaign. They have given up 12 touchdowns through the air as well as 224.0 yards per game, which has them sitting 78th in the nation. The Fighting Irish defense has been on the field for 665 plays, which is 65th in the nation. Their defense has 2 fumbles and 17 picks on the campaign. In total, they have allowed 184 total points.

Who will win tonight's Orange/Fighting Irish college football game against the spread?

Tony's Pick: Take the Orange +35.0

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