Syracuse Orange vs SMU Mustangs Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Syracuse Orange vs SMU Mustangs

Date: Saturday, October 4, 2025

Location: Gerald J. Ford Stadium in Dallas, TX

TV: ACC Network

Odds/Point Spread: Mustangs (-16.5)

Total/Over-Under: 58.5

The SMU Mustangs (2-2) will play the Syracuse Orange (3-2) at Gerald J. Ford Stadium on Saturday, October 4, 2025. Syracuse opens this contest as 16.5-point dogs from oddsmakers. The over/under has been set at 58.5.

The Syracuse Orange come into this matchup with a record of 3-2 for this season. The last time they took the field, the Orange took on the Duke Blue Devils and walked away from this one with a loss by a score of 38-3. Against the run, the Orange conceded 235 yards on 37 attempts, which calculates to 6.4 yds per run surrendered. Syracuse conceded 22 pass completions on 28 tries for 268 yards, and a completion rate of 78.6%. Overall, they had 64 plays for 314 yards. The Syracuse Orange ended up running the ball 27 different times and totaled 85 yards, which earned them an average of 3.1 yds per carry.

Concerning getting in the endzone, the Syracuse Orange hold an average of 31.2 PPG. As a team they average 112.0 yards via the ground game which is 115th in Division 1. The Orange have tallied 2,205 total yards for the year. In terms of distribution of touchdowns, Syracuse has earned 12 touchdowns via the pass and 8 touchdowns on the ground. Syracuse has a total of 123 first downs, and they have committed 25 penalties for 230 yds. They have surrendered the ball 9 different times.

When it comes to yards through the air, the Orange have given up 1,453 yds which ranks them 135th in the country. They have conceded 290.6 yards per contest through the air in addition to giving up a completion percentage of 60.5%. In total, they have allowed 464.6 yards per outing ranking them 126th in Division 1. They have surrendered 11 touchdowns by air in addition to 7 touchdowns via the ground game. They are allowing 5.4 yards per run and 174.0 yards on the ground per game this season. Over the course of this season, they have given up 870 rushing yards through 5 games. The Orange sit in 112th in Division 1 in terms of their opponents scoring, allowing 29.6 PPG.

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The Mustangs head into this game 2-2 for this season. When they last stepped on the gridiron, the Mustangs took a loss by a final score of 35-24 when they faced the TCU Horned Frogs. SMU gave up 37 running attempts for 138 yards (3.7 yds per rush). The Mustangs secondary conceded a completion percentage of 55.0%, surrendering 379 yards on 22 for 40 passing. The Mustangs finished the contest with a total of 384 yards on 65 plays (5.9 yards per play). SMU rushed the football for 3.5 yds per attempt, finishing with 94 yds on 27 attempts.

In terms of putting points on the board, the Mustangs are ranking 45th in the country with an average of 34.8 points per outing. The SMU Mustangs maintain an average of 422.5 yards per outing, which is good for 52nd in D-1. The SMU offense has accrued 339 yds of penalties on 33 infractions, which is 33rd in college football in terms of hurting your team. They have given away 5 picks while allowing opponents to recover 3 fumbles and they have been able to earn 91 first downs. During this campaign thus far, the Mustangs currently have a total of 1,126 passing yards as well as holding an average of 281.5 throwing yards per contest, which has them ranked 27th in Division 1. They have an average of 141.0 yards per game on the ground and have run for 564 yards for the year.

The Mustangs are giving up 26.5 points per game, which has them ranked 88th in the country. SMU has allowed the opposition a total of 459 yards rushing (114.8 yards per contest) and 3 touchdowns by way of the ground game for the year. They have yielded 10 touchdowns via the pass in addition to 334.5 yards per outing, which has them ranked 136th in D-1. The Mustangs defense has taken part in 314 plays, which is 86th in the nation. Their defense has compiled 3 fumbles recovered and 6 picks for the season. Overall, they have relinquished 106 pts.

Who will win tonight's Orange/Mustangs college football game against the spread?

Guy's Pick: Take the Mustangs -16.5

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