USC Trojans vs Purdue Boilermakers Prediction, 9/13/2025 College Football Picks, Best Bets & Odds

Game: USC Trojans vs Purdue Boilermakers

Date: Saturday, September 13, 2025

Location: Ross-Ade Stadium in West Lafayette, IN

TV: CBS Paramount+

Odds/Point Spread: Boilermakers (+21.0)

Total/Over-Under: 58.5

The Purdue Boilermakers (2-0) will play the USC Trojans (2-0) at Ross-Ade Stadium on Saturday, September 13, 2025. Purdue opens this contest as 21.0-point dogs. The over/under comes in at 58.5.

The USC Trojans step onto the field holding a record of 2-0 for this season. The last time they took the field, the Trojans faced off with the Georgia Southern Eagles and went home with a win by a final score of 59-20. The USC Trojans rushed the ball a total of 33 different times and totaled 309 yards, which had them averaging 9.4 yards per attempt. On the day, they ran 63 plays which gave them a total of 755 yds. USC surrendered 24 completions on 45 attempts for 235 yds, and a completion percentage of 53.3%. When it came to stopping the run, the Trojans gave up 142 yards on 33 tries, which is 4.3 yards per rush surrendered.

Regarding scoring points, the USC Trojans are sitting at 66.0 PPG. As a team they hold an average of 271.0 yards via the ground game which has them sitting 10th in college football. The Trojans have racked up 1,352 total yards this season. When it comes to getting in the endzone, USC has amassed 7 passing touchdowns and 10 touchdowns on the ground. USC has compiled 55 1st downs as a team, and they have been called for 13 infractions for 138 yards. They have given the ball to the opposition 2 times.

Regarding passing yards, the Trojans have conceded 394 yards which has them sitting in 68th in Division 1. They have relinquished 197.0 yards per game via the pass and giving up a completion percentage of 60.3%. Over the course of this season, they are giving up 300.5 yards per contest which has them sitting 54th in the nation. They have yielded 4 touchdowns via the pass. Opposing teams are running for an average of 3.3 yards per rush and 103.5 rushing yards per game so far this season. For the year, they have allowed 207 yards via the ground game in 2 games. The Trojans rank 58th in the nation in terms of team defense, conceding 16.5 points per game.

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The Boilermakers head into this game 2-0 for this season. When they last played, the Boilermakers walked away with a victory by a final of 34-17 when they faced the Southern Illinois Salukis. Purdue rushed for 4.0 yards per attempt, finishing with a total of 214 yds on 53 carries. The Boilermakers finished the game with a total of 384 yds and they ran 76 plays (5.1 yards per play). The Boilermakers passing defense allowed a completion rate of 58.8%, relinquishing 202 yds on 20 out of 34 passing. Purdue allowed 26 rushing attempts for 81 yds (3.1 yds per carry).

In terms of their ability to score points, the Boilermakers rank 52nd in Division 1 by tallying 32.5 points per game. The Purdue Boilermakers have an average of 408.5 yards/game, which has them sitting 65th in the nation. The Purdue offense has racked up 55 yards of penalties on 5 violations, which is 131st in Division 1 in terms of hurting your team. They have been able to record 52 first downs. During the season so far, the Boilermakers have a total of 510 passing yards as well as holding an average of 255.0 passing yards per outing, ranking them 46th in D-1. They are averaging 153.5 rushing yards per game and have toted the ball for 307 yards for the season.

Purdue has conceded a total of 197 rushing yards (98.5 yards per contest) in addition to 1 touchdown via the rush for the season. They have allowed 1 touchdown through the air as well as 144.5 yards/game, which has them sitting 29th in D-1. They defense has yet to create a turnover. The Boilermakers defense has participated in 112 plays, which ranks 23rd in the nation. The Boilermakers are conceding 8.5 PPG, which has them 16th in D-1.

Who will win tonight's Trojans/Boilermakers college football game against the spread?

Josh's Pick: Take the Boilermakers +21.0

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