UTSA Roadrunners vs Charlotte 49ers Prediction, 11/15/2025 College Football Picks, Best Bets & Odds

Game: UTSA Roadrunners vs Charlotte 49ers

Date: Saturday, November 15, 2025

Location: Jerry Richardson Stadium in Charlotte, NC

TV: ESPN+

Odds/Point Spread: 49ers (+17.5)

Total/Over-Under: 61

The Charlotte 49ers (1-7) will try to defeat the UTSA Roadrunners (4-5) at Jerry Richardson Stadium on Saturday, November 15, 2025. Charlotte opens as 17.5-point dogs from oddsmakers. The betting total is set at 61.

The UTSA Roadrunners come into this game with a record of 4-5 this season. In their last matchup, the Roadrunners faced the USF Bulls and took a loss by a score of 55-23. For the game, they ran 82 plays for 381 yds. The UTSA Roadrunners ended up rushing 38 times and amassed 72 yards, which earned them an average of 1.9 yards per tote. When it came to the battle of the line of scrimmage, the Roadrunners conceded 238 yds on 32 tries, which is 7.4 yds per run surrendered. UTSA allowed 16 pass completions on 18 attempts for 233 yds, and a completion percentage of 88.9%.

The Roadrunners have earned 3,598 total yards for the season. In terms of notching touchdowns, UTSA has totaled 21 passing touchdowns and 14 rushing touchdowns. They have turned the ball over 9 different times. UTSA has accumulated 184 first downs offensively, and they have committed 70 infractions for 642 yds. As a team they're averaging 166.4 yards in the run game which ranks them 53rd in the nation. When talking about scoring, the UTSA Roadrunners are sitting at 32.8 points per contest.

The Roadrunners are ranked 122nd in Division 1 in terms of the opposition scoring, conceding 33.0 PPG. They are giving up an average of 4.5 yards per rushing attempt and 158.2 rushing yards per contest for the season. In total, they have given up 1,424 yards via the ground game in 9 games. Regarding yards through the air, the Roadrunners are allowing 2,260 yds which ranks them 120th in college football. They have relinquished 251.1 yards per outing via the pass as well as allowing a completion percentage of 64.0%. Overall, they are giving up 409.3 yards per contest ranking them 109th in Division 1. They have relinquished 21 touchdowns via the pass in addition to 14 touchdowns on the ground.

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The 49ers head into this game 1-7 for this year. For their last game, the 49ers took a loss by a score of 48-22 when they faced the East Carolina Pirates. Charlotte conceded 44 rush attempts for 183 yards (4.2 yds per rush). The 49ers pass defense gave up a completion percentage of 59.1%, relinquishing 224 yards on 26 for 44 passing. The 49ers finished the game with 324 yards on 64 plays (5.1 yds per play). Charlotte rushed the football for 1.4 yards per tote, finishing with a total of 40 yds on 28 attempts.

In terms of their scoring prowess, the 49ers are ranking 128th in D-1 maintaining an average of 17.5 points per game. The Charlotte 49ers hold an average of 324.9 yards/game, which has them sitting 115th in college football. The Charlotte offense has racked up 424 yards of penalties on 50 violations, which is 93rd in the country in terms of making mistakes. They have thrown 7 picks while allowing opponents to recover 9 fumbles and they have been able to earn 147 first downs. For the season so far, the 49ers have thrown for a total of 1,745 yards through the air as well as an average of 218.1 throwing yards per game, putting them at 82nd in the nation. They hold an average of 106.8 yards per game on the ground and have run for 854 yards for the season.

Charlotte has surrendered a total of 1,662 rushing yards (207.8 yards per outing) and 17 touchdowns on the ground for the campaign. They have allowed 20 touchdowns through the air and 270.1 yards per outing, which has them sitting 127th in college football. This season, they have conceded 298 total points. Their defense has tallied 5 fumbles recovered and 3 interceptions this season. The 49ers defense has been on the field for 574 plays, which is 71st in college football. The 49ers are relinquishing 37.3 PPG, ranking them 132nd in Division 1.

Who will win tonight's Roadrunners/49ers college football game against the spread?

Guy's Pick: Take the 49ers +17.5

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