Vanderbilt Commodores vs South Carolina Gamecocks Prediction, 9/13/2025 College Football Picks, Best Bets & Odds

Game: Vanderbilt Commodores vs South Carolina Gamecocks

Date: Saturday, September 13, 2025

Location: Williams-Brice Stadium in Columbia, SC

TV: SEC Network

Odds/Point Spread: Gamecocks (-5.5)

Total/Over-Under: 47

Williams-Brice Stadium is where the South Carolina Gamecocks (1-0) will compete against the Vanderbilt Commodores (2-0) on Saturday, September 13, 2025. South Carolina opens this contest as 5.5-point favorites. The total is 47.

The Vanderbilt Commodores come into this game with a record of 2-0 for this year. In their last contest, the Commodores faced off with the Virginia Tech Hokies and took home the win by a score of 44-20. The Vanderbilt Commodores ended up rushing 37 different times and totaled 262 yds, earning them an average of 7.1 yds per carry. Overall, they had 57 plays which gave them a total of 490 yds. Vanderbilt gave up 17 pass completions on 29 attempts for a total of 134 yards, and a completion rate of 58.6%. When it came to stopping the run, the Commodores gave up 114 yards on 31 attempts, which calculates to 3.7 yds per run surrendered.

The Commodores have racked up 971 total yards for the year. When it comes to getting in the endzone, Vanderbilt has earned 6 passing touchdowns and 6 rushing touchdowns. They have surrendered the ball 2 different times. Vanderbilt has accrued 48 1st downs as a team, and they have committed 18 penalties for 137 yards. As a unit they hold an average of 231.5 yards via the ground game giving them a rank of 27th in college football. Regarding getting in the endzone, the Vanderbilt Commodores have an average of 44.5 PPG.

Regarding passing yardage, the Commodores have given up 221 yds which puts them in 15th in college football. They have yielded 110.5 yards per game through the air and allowed a completion percentage of 56.3%. Over the course of this season, they have relinquished 191.5 yards/outing putting them at 6th in the country. They have conceded 1 touchdown by air in addition to 1 touchdown running the ball. They are allowing an average of 2.8 yards per run and 81.0 yards on the ground per game this season. During this campaign, they have conceded 162 running yards through 2 contests. The Commodores are sitting in 34th in D-1 regarding team defense, allowing 11.5 points per contest.

Get all of our College Football Picks this Week

The Gamecocks head into this matchup 1-0 for this season. The last time they took the field, the Gamecocks walked away with a victory by a final of 38-10 against the South Carolina State Bulldogs. South Carolina rushed the football for 3.5 yards per carry, finishing the game with 125 yds on 36 attempts. The Gamecocks finished the contest with a total of 253 yds while running 56 plays (4.5 yards per play). The Gamecocks secondary gave up a completion rate of 64.3%, surrendering 208 yds on 18 out of 28 through the air. South Carolina surrendered 34 running attempts for 62 yards (1.8 yards per rush).

The South Carolina Gamecocks hold an average of 290.5 yards per contest, which ranks them 118th in the nation. The South Carolina offense has totaled 99 penalty yds on 15 infractions, ranking them 34th in the nation in terms of helping out the other team. They have an average of 122.0 yards per game on the ground and have run for 244 yards for the season. They recorded 32 first downs. When it comes to how much they score, the Gamecocks are 57th in D-1 scoring 31.0 points per game. For the year thus far, the Gamecocks have racked up 337 yards through the air as well as holding an average of 168.5 passing yards per game, which has them ranked 106th in the nation.

The Gamecocks are surrendering 10.5 points per contest, ranking them 26th in Division 1. South Carolina has surrendered a total of 177 rushing yards (88.5 yards/game) and 0 touchdowns via the rush this season. They have given up 1 touchdown through the air and 214.5 yards per game, which puts them in 83rd in Division 1. The Gamecocks defense has been on the field for 134 plays, which ranks 87th in the nation. Their defense has tallied 1 fumble and 2 interceptions so far this season.

Who will win tonight's Commodores/Gamecocks college football game against the spread?

Guy's Pick: Take the Commodores +5.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here