Virginia Cavaliers vs Duke Blue Devils Prediction, 11/15/2025 College Football Picks, Best Bets & Odds

Game: Virginia Cavaliers vs Duke Blue Devils

Date: Saturday, November 15, 2025

Location: Wallace Wade Stadium in Durham, NC

TV: ESPN2

Odds/Point Spread: Blue Devils (-6.0)

Total/Over-Under: 58.5

The Virginia Cavaliers (8-1) are on their way to Wallace Wade Stadium on Saturday, November 15, 2025 where they will compete against the Duke Blue Devils (5-3). Virginia opens this contest as 6.0-point underdogs. The betting total comes in at 58.5.

The Virginia Cavaliers step onto the field holding a record of 8-1 for this season. The last time they stepped onto the field, the Cavaliers took the field against the Wake Forest Demon Deacons and walked away from this one with a loss by a score of 16-9. Overall, they ran 64 plays which totaled 327 yds. The Virginia Cavaliers ran the football 30 different times and tallied 163 yards, earning them an average of 5.4 yards per tote. On the ground, the Cavaliers gave up 139 yds on 41 tries, which is an average of 3.4 yds per rush surrendered. Virginia allowed 9 pass completions on 23 tries for a total of 64 yards, and a completion percentage of 39.1%.

Concerning scoring points, the Virginia Cavaliers are averaging 36.4 points per contest. As a team they average 186.7 yards on the ground which ranks them 32nd in the country. The Cavaliers have attained 3,951 total yards for the year. When it comes to getting in the endzone, Virginia has compiled 13 passing touchdowns and 24 rushing touchdowns. Virginia has amassed 199 first downs as a team, and they have been called for 50 infractions for 423 yards. They have turned the football over 6 different times.

The Cavaliers sit in 52nd in D-1 in terms of team defense, allowing 22.2 points per contest. Opposing teams are running for an average of 3.4 yards per running attempt and 111.0 yards on the ground per contest for the season. For the year, they have given up 999 running yards through 9 contests. Regarding yards through the air, the Cavaliers have conceded 2,086 yds which has them ranked 102nd in Division 1. They have conceded 231.8 yards per outing via the pass and conceding a completion percentage of 63.0%. In total, they have allowed 342.8 yards per contest which puts them 45th in the country. They have surrendered 11 touchdowns via the pass in addition to 15 touchdowns running the ball.

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The Blue Devils head into this matchup 5-3 this season. When they last stepped on the field, the Blue Devils went home defeated by a final of 37-34 against the Connecticut Huskies. Duke gave up 30 rushing attempts for 156 yds (5.2 yards per carry). The Blue Devils pass defense gave up a completion rate of 67.5%, relinquishing 311 yards on 27 out of 40 passing. The Blue Devils finished the game with 390 yds and they ran 65 plays (6.0 yds per play). Duke rushed the football for 4.9 yards per tote, totaling 168 yards on 34 carries.

In relation to their ability to score points, the Blue Devils are sitting 25th in the country with 35.4 PPG. The Duke Blue Devils maintain an average of 460.3 yards per outing, which has them ranked 18th in the country. The Duke offense has totaled 561 yds of penalties on 59 violations, which is good for 45th in the country in terms of making mistakes. They have thrown 2 picks while allowing opponents to recover 6 fumbles and they have been able to record 188 1st downs. For the year thus far, the Blue Devils have compiled 2,594 passing yards in addition to an average of 324.3 throwing yards per outing, which ranks 4th in the nation. They have an average of 136.0 run yards per game and have rushed for 1,088 yards for this year.

The Blue Devils are relinquishing 28.1 points per game, which has them sitting 97th in the nation. Duke has yielded a total of 1,085 rushing yards (135.6 yards per contest) in addition to 20 touchdowns via the rush so far this year. They have given up 8 touchdowns through the air and 263.3 yards/game, which has them in 123rd in college football. The Blue Devils defense has participated in 526 plays, which has them ranked 26th in college football. They have compiled 5 fumbles and 8 picks for the year. Overall, they have conceded 225 total points.

Who will win tonight's Cavaliers/Blue Devils college football game against the spread?

Tony's Pick: Take the Blue Devils -6.0

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