Virginia Cavaliers vs Louisville Cardinals Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Virginia Cavaliers vs Louisville Cardinals

Date: Saturday, October 4, 2025

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ESPN2

Odds/Point Spread: Cardinals (-7.0)

Total/Over-Under: 62.5

L&N Federal Credit Union Stadium is the site where the Louisville Cardinals (4-0) will attempt to defeat the Virginia Cavaliers (4-1) on Saturday, October 4, 2025. Louisville opens as 7.0-point favorites. The total comes in at 62.5.

The Virginia Cavaliers come into this matchup with a record of 4-1 for this year. In their last game, the Cavaliers faced the Florida State Seminoles and walked away with a win by a score of 46-38. In the game, they ran 84 plays for 440 yds. The Virginia Cavaliers ran the rock 48 different times and amassed 211 yards, which earned them an average of 4.4 yards per tote. On the ground, the Cavaliers gave up 256 yds on 48 attempts, which is 5.3 yds per rush surrendered. Virginia relinquished 19 completions on 33 tries for 258 yards, and a completion percentage of 57.6%.

When talking about scoring, the Virginia Cavaliers have an average of 45.6 points per contest. Offensively they have an average of 243.4 yards on the ground ranking this team at 12th in college football. The Cavaliers have earned 2,698 yards in total this year. When it comes to distribution of touchdowns, Virginia has totaled 11 touchdowns through the air and 17 touchdowns on the ground. Virginia has a total of 133 first downs as a team, and they have committed 26 infractions for 185 yards. They have surrendered the football 5 times.

The Cavaliers rank 67th in Division 1 regarding team defense, allowing 23.2 points per game. Opposing teams are running for an average of 3.9 yards per rushing attempt and 131.4 yards on the ground per contest so far this season. For the year, they have conceded 657 rushing yards through 5 contests. In terms of yards through the air, the Cavaliers are conceding 1,111 yards which puts them in 103rd in D-1. They are giving up 222.2 yards per contest via the pass and conceding a completion percentage of 59.9%. In total, they are conceding 353.6 yards per contest ranking them 64th in college football. They have yielded 6 touchdowns via the pass as well as 10 touchdowns on the ground.

Get all of our Free College Football Picks

The Cardinals come into this matchup with a record of 4-0 for this year. When they last stepped on the field, the Cardinals went home victorious with a score of 34-27 when they played the Pittsburgh Panthers. The Cardinals finished with 392 yds on 85 plays (4.6 yards per play). Louisville ran the ball for 1.6 yds per carry, totaling 53 yards on 34 carries. Louisville conceded 23 attempts on the ground for 80 yds (3.5 yards per carry). The Cardinals passing defense gave up a completion rate of 53.1%, surrendering 259 yards on 17 for 32 passing.

When discussing putting points on the board, the Cardinals are ranked 24th in the nation holding an average of 38.3 PPG. The Louisville Cardinals have an average of 409.3 yards/game, which has them sitting 60th in college football. The Louisville offense has compiled 302 penalty yds on 32 infractions, ranking them 36th in Division 1 in terms of hurting your team. They have tossed 4 interceptions while allowing opponents to recover 2 fumbles and they have been able to record 84 first downs. During this campaign thus far, the Cardinals have racked up 1,116 yards through the air not to mention holding an average of 279.0 throwing yards per contest, putting them at 29th in the country. They hold an average of 130.3 rushing yards per game and have run for 521 yards for this season.

The Cardinals are giving up 18.8 points per contest, ranking them 41st in the nation. Louisville has conceded a total of 470 yards rushing (117.5 yards per contest) as well as 3 touchdowns rushing so far this season. They have allowed the opposition 4 touchdowns through the air and 150.8 yards/outing, which has them ranked 15th in the country. The Cardinals defense has taken part in 236 plays, which is 12th in the country. They have compiled 3 fumbles and 6 interceptions for the year. Overall, they have surrendered 75 points in total.

Who will win tonight's Cavaliers/Cardinals college football game against the spread?

Tony's Pick: Take the Cavaliers +7.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here