Virginia Cavaliers vs Missouri Tigers Prediction, 12/27/2025 College Football Picks, Best Bets & Odds

Game: Virginia Cavaliers vs Missouri Tigers

Date: Saturday, December 27, 2025

Location: EverBank Stadium in Jacksonville, FL

TV: ABC

Odds/Point Spread: Tigers (-4.0)

Total/Over-Under: 45

The Missouri Tigers (8-4) will play the Virginia Cavaliers (10-3) at EverBank Stadium on Saturday, December 27, 2025 in the TaxSlayer Gator Bowl. Missouri opens this contest as 4.0-point favorites. The total has been set at 45.

The Virginia Cavaliers come into this matchup with a record of 10-3 this season. The last time they stepped onto the field, the Cavaliers took on the Duke Blue Devils and ended up losing by a score of 27-20. The Virginia Cavaliers ran the football 29 times and amassed 128 yards, which had them averaging 4.4 yards per tote. Once the final whistle blew, they had 69 plays which converted into 344 yds. Virginia allowed 19 completions on 25 attempts for 196 yds, and a completion percentage of 76.0%. Against the rush, the Cavaliers conceded 137 yards on 44 tries, which calculates to 3.1 yds per rush allowed.

In terms of putting the ball in the endzone, the Virginia Cavaliers are sitting at 32.2 PPG. As a team they maintain an average of 184.0 yards rushing ranking this team at 37th in D-1. The Cavaliers have racked up 5,542 total yards this season. When it comes to notching touchdowns, Virginia has earned 18 touchdowns via the pass and 29 touchdowns via the ground. Virginia has recorded 285 first downs as a unit, and they have committed 72 infractions for 588 yds. They have turned the football over 13 times.

The Cavaliers are ranked 31st in the nation concerning their opponents scoring, giving up 20.5 PPG. They are allowing teams to run for an average of 3.3 yards per rush and 110.5 rushing yards per contest this season. In total, they have conceded 1,437 rushing yards through 13 games. In terms of passing yardage, the Cavaliers have conceded 2,636 yards which has them ranked 60th in the nation. They have given up 202.8 yards per game through the air as well as allowing a completion percentage of 59.9%. Overall, they are giving up 313.3 yards per outing which has them ranked 24th in the nation. They have conceded 16 touchdowns via the pass in addition to 16 touchdowns on the ground.

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The Tigers head into this matchup 8-4 for this season. In their last game, the Tigers got the win with a final of 31-17 against the Arkansas Razorbacks. The Tigers finished the contest with a total of 347 yds while running 65 plays (5.3 yds per play). Missouri rushed for 5.6 yards per tote, finishing with a total of 322 yds on 58 carries. Missouri relinquished 25 rush attempts for 61 yds (2.4 yards per carry). The Tigers pass defense allowed a completion percentage of 56.7%, surrendering 185 yds on 17 for 30 through the air.

Regarding this team's ability to score points, the Tigers currently rank 30th in college football averaging 32.2 points per outing. The Missouri Tigers are averaging 429.3 yards/game, ranking them 25th in the country. The Missouri offense has accrued 625 penalty yds on 66 infractions, which ranks 99th in Division 1 in terms of helping out the opposition. They have thrown 10 picks while conceding 6 fumbles and they have been able to obtain 286 1st downs. During this campaign thus far, the Tigers have thrown for a total of 2,344 passing yards as well as holding an average of 195.3 passing yards per game, which has them ranked 103rd in the nation. They average 234.1 yards per game via the ground game and have run for 2,809 yards overall.

Missouri has allowed a total of 1,240 yards via the ground game (103.3 yards per game) and 11 touchdowns by way of the ground game on the year. They have allowed the opposition 16 touchdowns from the passing game in addition to 171.4 yards/game, which has them ranked 11th in the country. This year, they have relinquished 233 total points. They have totaled 4 fumbles recovered and 7 interceptions on the campaign. The Tigers defense has been on the field for 718 plays, which is good for 8th in college football. The Tigers are surrendering 19.4 PPG, which puts them 23rd in D-1.

Who will win tonight's Cavaliers/Tigers college football game against the spread?

Guy's Pick: Take the Tigers -4.0

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