Western Kentucky Hilltoppers vs LSU Tigers Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Western Kentucky Hilltoppers vs LSU Tigers

Date: Saturday, November 22, 2025

Location: Tiger Stadium in Baton Rouge, LA

TV: SEC Network

Odds/Point Spread: Tigers (-23.0)

Total/Over-Under: 50

Tiger Stadium is the location where the LSU Tigers (6-4) will take on the Western Kentucky Hilltoppers (8-2) on Saturday, November 22, 2025. Western Kentucky opens this contest as 23.0-point dogs from oddsmakers. The betting total is set at 50.

The Western Kentucky Hilltoppers step onto the field holding a record of 8-2 this season. In their last matchup, the Hilltoppers took on the MTSU Blue Raiders and earned the victory with a final of 42-26. In all, they ran 79 plays which converted into 642 yds. The Western Kentucky Hilltoppers ran the rock 38 different times and recorded 271 yards, which came out to an average of 7.1 yds per attempt. Against the run, the Hilltoppers gave up 66 yards on 26 attempts, which is 2.5 yards per rush surrendered. Western Kentucky gave up 13 pass completions on 40 attempts for 112 yards, and a completion rate of 32.5%.

When it comes to scoring, the Western Kentucky Hilltoppers have an average of 31.3 PPG. As a team they maintain an average of 136.8 yards on the ground ranking them 92nd in the country. The Hilltoppers have attained 4,329 total yards for the season. When it comes to getting the ball in the endzone, Western Kentucky has earned 21 touchdowns through the air and 16 rushing touchdowns. Western Kentucky has a total of 225 1st downs as an offense, and they have been hurt by 62 penalties for 627 yards. They have turned the ball over 14 times.

Concerning yards through the air, the Hilltoppers have allowed 2,233 yds which puts them in 73rd in the nation. They have conceded 223.3 yards per contest through the air as well as giving up a completion percentage of 54.8%. In total, they have allowed 399.0 yards per contest which puts them 97th in the nation. They have yielded 8 touchdowns via the pass and 12 touchdowns running the ball. They are allowing an average of 5.1 yards per rush and 175.7 rushing yards per game for the season. Overall, they have conceded 1,757 yards via the ground game in 10 games. The Hilltoppers sit in 54th in the nation when it comes to team defense, allowing 23.1 points per contest.

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The Tigers come into this matchup with a record of 6-4 for this season. When they last played, the Tigers got the victory with a final of 23-22 when they played the Arkansas Razorbacks. LSU ran the ball for 4.2 yards per attempt, finishing with 155 yds on 37 carries. The Tigers finished the game with a total of 390 yards and they ran 70 plays (5.6 yds per play). The Tigers secondary conceded a completion rate of 61.1%, relinquishing 288 yds on 22 for 36 passing. LSU relinquished 26 rush attempts for 56 yards (2.2 yds per carry).

Concerning the points being put on the board, the Tigers sit 98th in Division 1 holding an average of 23.6 PPG. The LSU Tigers have an average of 346.6 yards/contest, which has them ranked 98th in college football. The LSU offense has accrued 582 penalty yds on 69 violations, which is good for 40th in Division 1 in terms of making mistakes. They have thrown 5 picks while conceding 5 fumbles and they have tallied 198 1st downs. Over the course of the season thus far, the Tigers have earned 2,402 yards via the pass in addition to holding an average of 240.2 throwing yards per game, giving them a rank of 61st in Division 1. They average 106.4 yards per game via the ground game and have toted the ball for 1,064 yards in total.

LSU has conceded a total of 1,309 yards via the ground game (130.9 yards per outing) as well as 14 touchdowns via the rush on the year. They have given up 8 touchdowns through the air and 198.2 yards/game, which has them in 42nd in D-1. Overall, they have allowed 193 points in total. They have tallied 4 fumbles and 12 interceptions for the season. The Tigers defense has participated in 634 plays, which is good for 30th in the nation. The Tigers are conceding 19.3 points per game, ranking them 21st in Division 1.

Who will win tonight's Hilltoppers/Tigers college football game against the spread?

Tony's Pick: Take the Hilltoppers +23.0

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