Wyoming Cowboys vs Colorado Buffaloes Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: Wyoming Cowboys vs Colorado Buffaloes

Date: Saturday, September 20, 2025

Location: Folsom Field in Boulder, CO

TV: ESPN

Odds/Point Spread: Buffaloes (-13.0)

Total/Over-Under: 44

The Wyoming Cowboys (2-1) are on their way to Folsom Field on Saturday, September 20, 2025 where they will take on the Colorado Buffaloes (1-2). Wyoming opens this contest as 13.0-point dogs. The over/under is set at 44.

The Wyoming Cowboys step onto the field holding a record of 2-1 for this year. In their last game, the Cowboys played the Utah Utes and walked away from this one with a loss by a score of 31-6. On the day, they tallied 57 plays which gave them a total of 229 yds. The Wyoming Cowboys rushed the ball a total of 34 different times and tallied 121 yards, which came out to an average of 3.6 yards per attempt. When it came to stopping the run, the Cowboys conceded 311 yards on 45 attempts, which is an average of 6.9 yds per run allowed. Wyoming conceded 27 completions on 41 tries for a total of 230 yds, and a completion rate of 65.9%.

When it comes to putting the ball in the endzone, the Wyoming Cowboys have an average of 15.7 PPG. As a unit they're averaging 158.7 yards via the ground game which has them sitting 73rd in D-1. The Cowboys have tallied 1,034 total yards for this campaign. When it comes to notching touchdowns, Wyoming has compiled 3 passing touchdowns and 3 touchdowns via the ground. Wyoming has accrued 59 first downs as an offense, and they have been called for 25 infractions for 200 yards. They have given the ball to the opposition 4 times.

The Cowboys are ranked 27th in the nation in terms of team defense, conceding 12.7 points per game. The opposition is running for 4.5 yards per rush on the ground and 153.0 rushing yards per game for the season. For the season, they have given up 459 running yards through 3 contests. Concerning yards through the air, the Cowboys have given up 480 yards which ranks them 42nd in D-1. They are giving up 160.0 yards per outing via the pass as well as giving up a completion percentage of 54.7%. In total, they have yielded 313.0 yards/game which has them sitting 52nd in the nation. They have allowed 2 touchdowns by air and 3 touchdowns on the ground.

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The Buffaloes come into this game with a record of 1-2 for this season. The last time they took the field, the Buffaloes took a defeat with a final score of 36-20 when they faced the Houston Cougars. The Buffaloes finished the game with a total of 300 yards while they ran 58 plays (5.2 yards per play). Colorado ran the ball for 4.2 yds per carry, finishing the contest with 96 yds on 23 attempts. Colorado allowed 53 run attempts for 209 yds (3.9 yds per rush). The Buffaloes passing defense allowed a completion rate of 62.5%, relinquishing 222 yds on 15 for 24 through the air.

The Colorado Buffaloes are averaging 334.3 yards/contest, which has them ranked 104th in Division 1. The Colorado offense has compiled 130 penalty yards on 15 infractions, which ranks them 85th in Division 1 in terms of giving up free yards. They have an average of 124.0 run yards per game and have rushed for 372 yards for the season. They have thrown 2 picks while conceding 0 fumbles and they have tallied 55 1st downs. In relation to the points being put on the board, the Buffaloes sit 95th in the country averaging 23.7 PPG. For the year thus far, the Buffaloes currently have a total of 631 yards via the pass as well as an average of 210.3 throwing yards per outing, which has them ranked 82nd in Division 1.

Colorado has given up a total of 613 yards rushing (204.3 yards/game) in addition to 6 touchdowns rushing on the season. They have given up 1 touchdown through the air and 225.7 yards per game, ranking them 90th in the nation. This year, they have given up 70 total points. Their defense has compiled 3 fumbles recovered and 2 interceptions on the year. The Buffaloes defense has participated in 211 plays, which has them ranked 109th in the nation. The Buffaloes are surrendering 23.3 PPG, which puts them 74th in the country.

Who will win tonight's Cowboys/Buffaloes college football game against the spread?

Tony's Pick: Take the Buffaloes -13.0

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