Buffalo Bulls vs Penn State Nittany Lions Prediction, 9/19/2026 College Football Picks, Best Bets & Odds

Game: Buffalo Bulls vs Penn State Nittany Lions

Date: Saturday, September 19, 2026

Location: Beaver Stadium in University Park, PA

TV: BTN

Odds/Point Spread: Nittany Lions (-41.5)

Total/Over-Under: 47.5

Beaver Stadium is where the Penn State Nittany Lions (2-0) will take on the Buffalo Bulls (1-1) on Saturday, September 19, 2026. Penn State opens as 41.5-point favorites. The total has been set at 47.5.

The Buffalo Bulls head into this game 1-1 for this year. In their last contest, the Bulls faced off with the FIU Panthers and walked away from this one with a loss by a score of 33-20. The Buffalo Bulls rushed the ball a total of 25 times and tallied 53 yards, which is an average of 2.1 yds per attempt. For the game, they had 66 plays which gave them a total of 302 yds. Buffalo allowed 22 completions on 37 tries for 386 yards, and a completion rate of 59.5%. Against the rush, the Bulls gave up 154 yards on 39 tries, which averages out to 3.9 yards per run surrendered.

Concerning putting points on the board, the Buffalo Bulls hold an average of 20.5 PPG. As a unit they have an average of 102.0 yards rushing which ranks them 122nd in the nation. The Bulls have tallied 642 total yards this season. In terms of scoring touchdowns, Buffalo has earned 5 passing touchdowns and no touchdowns on the ground. Buffalo has earned 31 1st downs as a unit, and they have been hurt by 15 infractions for 148 yards. They have turned the ball over 4 times.

The Bulls rank 90th in college football in terms of the opposition scoring, conceding 25.0 points per game. They are allowing 3.2 yards per rush on the ground and 113.0 rushing yards per contest on the season. Over the course of this year, they have allowed 226 yards via the ground game in 2 outings. Regarding passing yards, the Bulls have given up 590 yds which ranks them 125th in college football. They have yielded 295.0 yards per outing through the air in addition to conceding a completion percentage of 52.6%. For the season, they are conceding 408.0 yards/game which has them sitting 113th in the nation. They have yielded 6 touchdowns by air and no TD's pounding the rock.

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The Nittany Lions head into this game 2-0 for this season. The last time they took the field, the Nittany Lions walked away with a victory by a final of 27-9 when they faced the Temple Owls. The Nittany Lions finished with 416 yds while running 61 plays (6.8 yds per play). Penn State ran the ball for 4.4 yds per carry, finishing the game with 148 yds on 34 attempts. Penn State gave up 33 rush attempts for 176 yards (5.3 yards per carry). The Nittany Lions secondary conceded a completion rate of 59.1%, surrendering 107 yds on 13 out of 22 through the air.

When discussing their ability to score points, the Nittany Lions are sitting 52nd in college football with an average of 36.0 points per outing. The Penn State Nittany Lions have an average of 451.5 yards per outing, which ranks them 40th in college football. The Penn State offense has accrued 65 penalty yards on 8 infractions, which ranks them 117th in D-1 in terms of giving up free yards. They have thrown no picks while conceding no fumbles and they have been able to earn 48 1st downs. During the season thus far, the Nittany Lions have thrown for a total of 592 passing yards in addition to holding an average of 296.0 passing yards per contest, giving them a rank of 29th in the country. They have an average of 155.5 yards via the ground game and have toted the ball for 311 yards for the year.

The Nittany Lions are giving up 4.5 PPG, ranking them 1st in the nation. Penn State has conceded a total of 220 yards via the ground game (110.0 yards per game) as well as 1 touchdown on the ground so far this season. They have allowed no TD's via the pass in addition to 105.0 yards/game, which puts them in 4th in college football. The Nittany Lions defense has taken part in 109 plays, which ranks 18th in D-1. They have earned 1 fumble and 2 interceptions on the campaign.

Who will win tonight's Bulls/Nittany Lions college football game against the spread?

Josh's Pick: Take the Nittany Lions -41.5

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