Clemson Tigers vs LSU Tigers Prediction, 9/5/2026 College Football Picks, Best Bets & Odds

Game: Clemson Tigers vs LSU Tigers

Date: Saturday, September 5, 2026

Location: Tiger Stadium in Baton Rouge, LA

TV: ESPN+

Odds/Point Spread: Tigers (-10.5)

Total/Over-Under: 51

The LSU Tigers (7-6 last year) will play the Clemson Tigers (7-6 last season) at Tiger Stadium on Saturday, September 5, 2026. Clemson is 10.5-point dogs from oddsmakers. The betting total is set at 51.

The Clemson Tigers wrapped up their year holding a 7-6 mark. In their last matchup, the Tigers stepped onto the field against the Penn State Nittany Lions and took a loss by a score of 22-10. On the ground, the Tigers gave up 135 yards on 41 tries, which averages out to 3.3 yards per rush surrendered. Clemson conceded 23 pass completions on 35 tries for 262 yards, and a completion rate of 65.7%. When all was said and done, they tallied 65 plays which gave them a total of 236 yards. The Clemson Tigers ran the rock 25 times and tallied 43 yds, which had them averaging 1.7 yards per attempt.

The Tigers had 5,099 yards in total for last season. Clemson earned 22 touchdowns through the air and 20 touchdowns via the ground. They surrendered the football 16 different times. Clemson amassed 274 1st downs as a team, and they were called for 57 infractions for 547 yds. As a unit they held an average of 124.5 yards in the run game, ranking them 105th in Division 1. In terms of scoring points, the Clemson Tigers were sitting at 27.2 points per outing.

The Tigers were sitting in 31st in Division 1 when it comes to team defense, giving up 20.5 points per game. The opposition ran for an average of 3.5 yards per running attempt and 105.5 rushing yards per contest over the course of last season. For the season, they conceded 1,372 yards on the ground in 13 games. In terms of passing yardage, the Tigers gave up 3,266 yds which had them ranked 125th in the nation. Over the course of their 13 games played last year, they yielded 251.2 yards per game via the pass in addition to surrendering a completion percentage of 60.8%. They granted 356.7 yards per outing which put them 55th in the country. They granted 18 passing touchdowns as well as 10 touchdowns on the ground.

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The Tigers wrapped up their year having earned a 7-6 record. When they last played, the Tigers walked away with a loss by a score of 38-35 when they faced the Houston Cougars. LSU ran the ball for 3.2 yds per attempt, totaling 77 yds on 24 carries. The Tigers finished the game with 344 yards while they ran 50 plays (6.9 yds per play). The Tigers pass defense conceded a completion percentage of 75.0%, relinquishing 236 yds on 27 for 36 passing. LSU surrendered 46 rush attempts for 201 yards (4.4 yards per rush).

The LSU Tigers held an average of 333.5 yards per game, which ranked them 111th in the country. The LSU offense accrued 771 penalty yds on 91 infractions, which was 30th in college football in terms of helping out the other team. They held an average of 104.0 run yards per game and ran for 1,352 yards overall. They threw 7 interceptions while letting opponents recover 7 fumbles and they earned 244 first downs. When looking at putting points on the board, the Tigers had a ranking of 103rd in college football with a maintained average of 22.8 points per outing. Last season, the Tigers threw for a total of 2,984 passing yards in addition to averaging 229.5 passing yards per game, putting them at 63rd in the country.

LSU allowed a total of 1,613 rushing yards (124.1 yards per game) and 16 touchdowns via the rush last season. They allowed 14 touchdowns through the air as well as 204.6 yards/game, ranking them 42nd in the nation. Overall, they gave up 257 total points. Their defense totaled 4 fumbles recovered and 17 picks for the previous season. The Tigers defense took part in 848 plays, which ranked them 72nd in the country. The Tigers conceded 19.8 PPG, ranking them 23rd in Division 1.

Who will win tonight's Tigers/Tigers college football game against the spread?

Tony's Pick: Take the Tigers +10.5

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