Clemson Tigers vs Syracuse Orange Prediction, 11/7/2026 College Football Picks, Best Bets & Odds

Game: Clemson Tigers vs Syracuse Orange

Date: Saturday, November 7, 2026

Location: JMA Wireless Dome in Syracuse, NY

TV: ESPN2

Odds/Point Spread: Orange (+1.5)

Total/Over-Under: 49.5

The Syracuse Orange (4-4) will try to beat the Clemson Tigers (5-3) at JMA Wireless Dome on Saturday, November 7, 2026. Syracuse opens as 1.5-point underdogs from Vegas oddsmakers. The betting total is set at 49.5.

The Clemson Tigers come into this game with a record of 5-3 for this season. In their last matchup, the Tigers faced off with the Florida State Seminoles and notched a win by a score of 36-24. On the ground, the Tigers conceded 65 yards on 29 tries, which averages out to 2.2 yds per run allowed. Clemson surrendered 21 completions on 33 tries for 350 yds, and a completion rate of 63.6%. When the final whistle blew, they ran 76 plays which totaled 351 yds. The Clemson Tigers ended up running the ball 44 different times and had 162 yards, earning them an average of 3.7 yards per attempt.

Regarding getting in the endzone, the Clemson Tigers are sitting at 23.3 points per outing. Offensively they're holding an average of 152.0 yards in the run game which is 74th in the nation. The Tigers have racked up 2,683 total yards over the course of this season. With reference to notching touchdowns, Clemson has earned 4 touchdowns through the air and 11 rushing touchdowns. Clemson has earned 157 first downs, and they have committed 56 penalties for 525 yds. They have turned the ball over 11 times.

When it comes to passing yards, the Tigers have conceded 1,650 yds which has them ranked 51st in D-1. They are conceding 206.3 yards per outing through the air and giving up a completion percentage of 58.5%. In total, they are granting 329.3 yards/contest ranking them 39th in the country. They have surrendered 9 touchdowns via the pass as well as 9 touchdowns via the ground game. They are allowing teams to run for an average of 3.6 yards per tote and 123.0 yards on the ground per game for the season. For the year, they have allowed 984 yards via the ground game in 8 contests. The Tigers are ranked 49th in the country when it comes to team defense, allowing 21.6 PPG.

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The Orange come into this game with a record of 4-4 for this season. When they last stepped on the gridiron, the Orange took home the win by a final score of 30-27 when they played the SMU Mustangs. Syracuse relinquished 31 rush attempts for 69 yards (2.2 yds per carry). The Orange passing defense gave up a completion percentage of 78.4%, surrendering 352 yds on 29 for 37 through the air. The Orange finished the game with 338 yards while they ran 71 plays (4.8 yards per play). Syracuse ran for 3.7 yds per attempt, finishing with a total of 138 yards on 37 attempts.

The Syracuse Orange are averaging 436.5 yards per contest, which is good for 30th in the country. The Syracuse offense has compiled 681 yards of penalties on 75 violations, which is good for 4th in the country in terms of giving up free yards. They have an average of 161.1 yards per game on the ground and have toted the ball for 1,289 yards for the season. They have thrown 9 interceptions while surrendering 1 fumbles and they have tallied 205 1st downs. When looking at their scoring prowess, the Orange rank 52nd in the nation averaging 31.4 PPG. For the season to this point, the Orange currently have a total of 2,203 passing yards along with an average of 275.4 passing yards per outing, which has them ranked 24th in the country.

Syracuse has conceded a total of 1,007 rushing yards (125.9 yards per game) in addition to 15 touchdowns on the ground for the year. They have surrendered 11 touchdowns from the passing game and 221.0 yards/outing, which has them ranked 83rd in the nation. Over the course of the season, they have surrendered 211 points. They have compiled 6 fumbles recovered and 4 picks this season. The Orange defense has taken part in 507 plays, which has them sitting 44th in the nation. The Orange are allowing 26.4 points per game, ranking them 90th in D-1.

Who will win tonight's Tigers/Orange college football game against the spread?

Tony's Pick: Take the Orange +1.5

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