Colorado Buffaloes vs Oklahoma State Cowboys Prediction, 10/24/2026 College Football Picks, Best Bets & Odds

Game: Colorado Buffaloes vs Oklahoma State Cowboys

Date: Saturday, October 24, 2026

Location: Boone Pickens Stadium in Stillwater, OK

TV: FS1

Odds/Point Spread: Cowboys (-14.5)

Total/Over-Under: 54.5

The Oklahoma State Cowboys (4-2) welcome the Colorado Buffaloes (2-4) at Boone Pickens Stadium on Saturday, October 24, 2026. Colorado is 14.5-point underdogs. The total is set at 54.5.

The Colorado Buffaloes head into this game 2-4 this year. In their last contest, the Buffaloes went up against the Utah Utes and walked away from this one with a loss by a score of 27-24. In the running game, the Buffaloes gave up 131 yards on 39 tries, which is an average of 3.4 yds per run allowed. Colorado gave up 24 pass completions on 41 tries for a total of 278 yds, and a completion rate of 58.5%. At the end of the game, they tallied 55 plays which totaled 394 yards. The Colorado Buffaloes ran the football 24 times and totaled 138 yds, which had them averaging 5.8 yds per carry.

When it comes to scoring points, the Colorado Buffaloes hold an average of 19.5 points per game. As a team they're averaging 140.3 yards on the ground which ranks them 95th in the country. The Buffaloes have tallied 2,365 yards in total for the year. When it comes to getting in the endzone, Colorado has amassed 10 passing touchdowns and 5 touchdowns via the ground. Colorado has recorded 127 1st downs, and they have been flagged for 55 infractions for 506 yds. They have surrendered the ball 13 different times.

The Buffaloes are sitting in 88th in the nation when it comes to team defense, giving up 25.7 PPG. They are giving up an average of 3.5 yards per tote and 130.3 yards on the ground per game this season. Over the course of this season, they have allowed 782 rushing yards through 6 games. In terms of yards through the air, the Buffaloes have allowed 1,361 yds which puts them in 70th in college football. They have yielded 226.8 yards per outing through the air and allowed a completion percentage of 56.8%. Over the course of this year, they have surrendered 357.2 yards/game which has them ranked 71st in D-1. They have surrendered 12 touchdowns via the pass as well as 3 touchdowns pounding the rock.

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The Cowboys come into this matchup with a record of 4-2 for this season. When they last stepped on the gridiron, the Cowboys took a defeat with a final score of 35-32 when they played the Houston Cougars. The Cowboys finished the contest with a total of 499 yards and they ran 59 plays (8.5 yards per play). Oklahoma State rushed for 5.4 yds per attempt, finishing the game with 134 yards on 25 attempts. Oklahoma State allowed 40 rushing attempts for 162 yds (4.1 yards per rush). The Cowboys passing defense allowed a completion rate of 72.7%, relinquishing 343 yds on 24 out of 33 through the air.

Concerning the points being put on the board, the Cowboys sit 22nd in D-1 by tallying 37.2 PPG. The Oklahoma State Cowboys have an average of 517.7 yards/game, which ranks them 5th in Division 1. The Oklahoma State offense has compiled 313 penalty yards on 32 violations, which has them sitting 122nd in the nation in terms of hurting your team. They have thrown 6 picks while conceding 5 fumbles and they have been able to earn 157 1st downs. During the season thus far, the Cowboys have earned 1,977 passing yards as well as an average of 329.5 throwing yards per game, which ranks 4th in the country. They hold an average of 188.2 yards per game on the ground and have toted the ball for 1,129 yards for the season.

The Cowboys are surrendering 23.7 points per contest, ranking them 71st in college football. Oklahoma State has allowed a total of 907 yards on the ground (151.2 yards per game) in addition to 6 touchdowns by way of the ground game on the year. They have given up 12 touchdowns through the air and 207.0 yards/outing, which has them sitting 66th in Division 1. The Cowboys defense has been on the field for 406 plays, which is 49th in college football. They have 2 fumbles and 5 interceptions this season. In total, they have surrendered 142 total points.

Who will win tonight's Buffaloes/Cowboys college football game against the spread?

Guy's Pick: Take the Cowboys -14.5

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