East Carolina Pirates vs Memphis Tigers Prediction, 10/22/2026 College Football Picks, Best Bets & Odds

Game: East Carolina Pirates vs Memphis Tigers

Date: Thursday, October 22, 2026

Location: Simmons Bank Liberty Stadium in Memphis, TN

TV: ESPN2

Odds/Point Spread: Tigers (-10.5)

Total/Over-Under: 53.5

The Memphis Tigers (5-2) will try to beat the East Carolina Pirates (3-3) at Simmons Bank Liberty Stadium on Thursday, October 22, 2026. Memphis opens as 10.5-point favorites from Vegas oddsmakers. The betting total is set at 53.5.

The East Carolina Pirates head into this game 3-3 for this season. In their last game, the Pirates stepped onto the field against the UAB Blazers and took a loss by a score of 30-17. Against the run, the Pirates conceded 99 yards on 32 tries, which is 3.1 yards per rush allowed. East Carolina relinquished 19 completions on 37 attempts for a total of 262 yards, and a completion percentage of 51.4%. On the day, they ran 77 plays which converted into 315 yds. The East Carolina Pirates ran the rock 50 different times and totaled 189 yards, which had them averaging 3.8 yards per attempt.

The Pirates have racked up 2,035 total yards over the course of this year. In terms of notching touchdowns, East Carolina has earned 11 passing touchdowns and 5 rushing touchdowns. They have turned the football over 10 times. East Carolina has accumulated 101 first downs as a team, and they have been flagged for 40 infractions for 383 yards. As a team they average 155.5 yards rushing which ranks them 70th in the nation. Regarding getting in the endzone, the East Carolina Pirates hold an average of 23.5 points per contest.

The Pirates rank 72nd in D-1 when it comes to their opponents scoring, allowing 23.8 PPG. They are allowing teams to run for an average of 3.2 yards per rush and 138.8 rushing yards per contest so far this year. For the year, they have allowed 833 rushing yards through 6 games. Concerning passing yards, the Pirates have conceded 1,125 yards which ranks them 22nd in Division 1. They have surrendered 187.5 yards per game via the pass and giving up a completion percentage of 54.7%. Overall, they are surrendering 326.3 yards per contest which puts them 37th in Division 1. They have conceded 3 touchdowns via the pass and 10 touchdowns running the ball.

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The Tigers come into this game with a record of 5-2 for this year. In their last game, the Tigers took a defeat with a final score of 31-17 when they played the Tulane Green Wave. The Tigers ended up finishing with 482 yds while running 81 plays (6.0 yards per play). Memphis rushed for 4.0 yards per attempt, finishing with 176 yds on 44 carries. Memphis gave up 38 run attempts for 150 yards (3.9 yds per rush). The Tigers pass defense conceded a completion rate of 54.5%, surrendering 175 yards on 12 out of 22 through the air.

The Memphis Tigers average 511.7 yards per contest, which ranks them 6th in the nation. The Memphis offense has totaled 310 penalty yards on 34 infractions, which is 111th in the country in terms of helping out the other team. They have an average of 236.9 run yards per game and have run for 1,658 yards in total. They have tossed 7 interceptions while allowing opponents to recover 4 fumbles and they have earned 176 first downs. In relation to how much they score, the Tigers are sitting 35th in college football with 35.4 PPG. During this campaign to this point, the Tigers have compiled 1,924 passing yards in addition to holding an average of 274.9 throwing yards per outing, which has them ranked 25th in D-1.

The Tigers are conceding 22.3 points per contest, which puts them 58th in the nation. Memphis has allowed a total of 1,210 yards rushing (172.9 yards per contest) in addition to 10 touchdowns via the rush for the campaign. They have allowed the opposition 7 touchdowns via the pass as well as 199.6 yards/outing, which has them sitting 55th in Division 1. The Tigers defense has been on the field for 441 plays, which has them sitting 92nd in Division 1. They have compiled 6 fumbles recovered and 7 picks on the year. This season, they have surrendered 156 total points.

Who will win tonight's Pirates/Tigers college football game against the spread?

Tony's Pick: Take the Pirates +10.5

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