Iowa State Cyclones vs Arizona Wildcats Prediction, 10/24/2026 College Football Picks, Best Bets & Odds

Game: Iowa State Cyclones vs Arizona Wildcats

Date: Saturday, October 24, 2026

Location: Casino Del Sol Stadium in Tucson, AZ

TV: ESPN2

Odds/Point Spread: Wildcats (-10.5)

Total/Over-Under: 51

Casino Del Sol Stadium is where the Arizona Wildcats (5-1) will try to beat the Iowa State Cyclones (3-3) on Saturday, October 24, 2026. Arizona is 10.5-point favorites from oddsmakers. The over/under is 51.

The Iowa State Cyclones step onto the field holding a record of 3-3 for this year. In their last contest, the Cyclones took the field against the BYU Cougars and walked away from this one with a loss by a score of 24-10. When it came to stopping the run, the Cyclones gave up 177 yards on 31 attempts, which is 5.7 yds per run allowed. Iowa State conceded 22 pass completions on 30 tries for a total of 329 yards, and a completion rate of 73.3%. In all, they ran 56 plays which totaled 200 yards. The Iowa State Cyclones ended up rushing 27 times and totaled 102 yds, which earned them an average of 3.8 yards per tote.

Regarding putting the ball in the endzone, the Iowa State Cyclones have an average of 29.7 PPG. As a team they're holding an average of 181.5 yards rushing which ranks them 47th in D-1. The Cyclones have racked up 2,158 total yards for this campaign. In terms of getting the ball in the endzone, Iowa State has earned 9 passing touchdowns and 11 touchdowns via the ground. Iowa State has recorded 115 first downs as an offense, and they have been called for 32 infractions for 282 yds. They have given the ball to the opposition 5 times.

Concerning passing yards, the Cyclones have allowed 1,191 yards which ranks them 33rd in the country. They have surrendered 198.5 yards per outing via the pass as well as allowing a completion percentage of 63.4%. In total, they are giving up 352.3 yards/contest which puts them 66th in college football. They have conceded 7 touchdowns via the pass and 9 touchdowns pounding the rock. The opposition is running for an average of 4.4 yards per run and 153.8 rushing yards per game for the season. During this campaign, they have allowed 923 yards via the ground game in 6 games. The Cyclones rank 51st in Division 1 regarding team defense, conceding 21.7 PPG.

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The Wildcats come into this game with a record of 5-1 for this season. When they last played, the Wildcats walked away with a victory by a final of 52-31 when they played the West Virginia Mountaineers. Arizona ran the ball for 5.2 yards per carry, finishing with 141 yds on 27 attempts. The Wildcats finished the game with 482 yds while they ran 51 plays (9.5 yards per play). The Wildcats passing defense conceded a completion rate of 39.3%, surrendering 219 yds on 11 for 28 passing. Arizona conceded 76 running attempts for 303 yards (4.0 yards per rush).

Regarding their ability to score points, the Wildcats are sitting 29th in the nation averaging 35.7 PPG. The Arizona Wildcats have an average of 456.5 yards per outing, which is good for 21st in the nation. The Arizona offense has totaled 341 yds of penalties on 36 infractions, which is 103rd in the nation in terms of giving up free yards. They have thrown 6 picks while allowing opponents to recover 2 fumbles and they have been able to earn 143 first downs. For the season thus far, the Wildcats have a total of 1,840 yards through the air not to mention an average of 306.7 passing yards per contest, which is ranked 10th in college football. They average 149.8 rushing yards per game and have toted the ball for 899 yards in total.

Arizona has given up a total of 698 yards rushing (116.3 yards per game) and 8 touchdowns via the rush for the campaign. They have given up 5 touchdowns through the air as well as 214.2 yards per game, which has them sitting 74th in D-1. Over the course of the season, they have relinquished 114 total points. Their defense has tallied 3 fumbles recovered and 2 interceptions on the season. The Wildcats defense has been on the field for 407 plays, ranking them 50th in Division 1. The Wildcats are relinquishing 19.0 points per contest, which has them 32nd in college football.

Who will win tonight's Cyclones/Wildcats college football game against the spread?

Tony's Pick: Take the Wildcats -10.5

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