Iowa State Cyclones vs Iowa Hawkeyes Prediction, 9/12/2026 College Football Picks, Best Bets & Odds

Game: Iowa State Cyclones vs Iowa Hawkeyes

Date: Saturday, September 12, 2026

Location: Kinnick Stadium in Iowa City, IA

TV: NBC

Odds/Point Spread: Hawkeyes (-14.5)

Total/Over-Under: 40.5

The Iowa State Cyclones (1-0) are on their way to Kinnick Stadium on Saturday, September 12, 2026 where they will play the Iowa Hawkeyes (1-0). Iowa State opens as 14.5-point dogs. The over/under is 40.5.

The Iowa State Cyclones head into this game 1-0 this season. In their last game, the Cyclones went up against the Southeast Missouri State Redhawks and went home with a win by a final score of 38-10. On the ground, the Cyclones conceded 67 yards on 45 attempts, which is 1.5 yards per run allowed. Iowa State surrendered 17 pass completions on 22 attempts for 142 yards, and a completion rate of 77.3%. At the end of the game, they tallied 48 plays which gave them 303 yds. The Iowa State Cyclones ran the football 31 different times and tallied 108 yards, which came out to an average of 3.5 yards per tote.

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Regarding getting in the endzone, the Iowa State Cyclones hold an average of 38.0 PPG. As a unit they are averaging 108.0 yards rushing giving them a rank of 107th in college football. The Cyclones have earned 303 total yards for this campaign. With reference to distribution of touchdowns, Iowa State has amassed 2 touchdowns via the pass and 3 rushing touchdowns. Iowa State has accounted for 15 first downs as a unit, and they have been flagged for 4 infractions for 40 yards. They have surrendered the ball 1 time.

The Cyclones rank 44th in D-1 when it comes to the opposition scoring, allowing 10.0 PPG. The opposition is running for an average of 1.5 yards per attempt on the ground and 67.0 rushing yards per game on the year. During the season, they have conceded 67 yards via the running game in 1 outing. When it comes to passing yards, the Cyclones have given up 142 yds which puts them in 47th in Division 1. They have conceded 142.0 yards per game via the pass and allowed a completion percentage of 77.3%. During the season, they are giving up 209.0 yards per game which ranks them 35th in the nation. They have given up no touchdowns by air in addition to 1 touchdown pounding the rock.

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The Hawkeyes head into this matchup 1-0 for this year. For their last game, the Hawkeyes walked away with a victory by a final of 40-0 when they faced the NIU Huskies. Iowa ran the ball for 7.6 yards per attempt, totaling 289 yds on 38 attempts. The Hawkeyes finished the game with 507 yards while running 78 plays (6.5 yds per play). The Hawkeyes pass defense allowed a completion percentage of 54.2%, relinquishing 113 yards on 13 for 24 passing. Iowa surrendered 31 rushing attempts for 7 yards (0.2 yds per rush).

Regarding their ability to score points, the Hawkeyes are 48th in D-1 averaging 40.0 PPG. The Iowa Hawkeyes maintain an average of 507.0 yards/game, which has them sitting 39th in the country. The Iowa offense has 60 yards of penalties on 7 infraction, which ranks 54th in D-1 in terms of hurting your team. They have given away 1 pick while surrendering no fumbles and they have been able to earn 26 first downs. During this campaign thus far, the Hawkeyes have thrown for a total of 218 passing yards. They hold an average of 289.0 yards per game via the ground game.

The Hawkeyes are giving up 0.0 points per contest, which has them 7th in D-1. Iowa has conceded a total of 7 rushing yards and no touchdowns on the ground this season. They have surrendered no touchdowns via the pass and 113.0 yards/outing, which has them ranked 30th in D-1. The Hawkeyes defense has been on the field for 55 plays, which has them ranked 32nd in D-1. They have compiled 1 fumble and 1 pick over the course of the season.

Who will win tonight's Cyclones/Hawkeyes college football game against the spread?

Tony's Pick: Take the Hawkeyes -14.5

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