Louisville Cardinals vs Ole Miss Rebels Prediction, 9/6/2026 College Football Picks, Best Bets & Odds

Game: Louisville Cardinals vs Ole Miss Rebels

Date: Sunday, September 6, 2026

Location: Nissan Stadium in Nashville, TN

TV: ESPN+

Odds/Point Spread: Rebels (-7.5)

Total/Over-Under: 55.5

The Ole Miss Rebels (13-2 last year) will play the Louisville Cardinals (9-4 last season) at Nissan Stadium on Sunday, September 6, 2026. Louisville is 7.5-point dogs from oddsmakers. The over/under comes in at 55.5.

The Louisville Cardinals wrapped up their year having earned a 9-4 record. The last time they took the field, the Cardinals took on the Toledo Rockets and earned the victory with a final of 27-22. In all, they ran 60 plays which converted into 333 yards. The Louisville Cardinals ran the ball 36 times and totaled 180 yds, which had them averaging 5.0 yards per attempt. On the ground, the Cardinals gave up 169 yds on 40 tries, which is 4.2 yards per run allowed. Louisville gave up 17 completions on 28 tries for 167 yds, and a completion rate of 60.7%.

In terms of getting in the endzone, the Louisville Cardinals had an average of 29.9 PPG. As a team they averaged 163.9 yards on the ground, which had them sitting 59th in D-1. The Cardinals tallied 4,999 yards in total over the course of last year. Louisville compiled 18 passing touchdowns and 25 rushing touchdowns. Louisville tallied 257 1st downs as a unit, and they committed 90 penalties for 822 yards. They turned the football over 17 times.

In terms of passing yards, the Cardinals gave up 2,454 yards which ranked them 27th in Division 1. Over the course of their 13 games, they yielded 188.8 yards per game through the air and relinquishing a completion percentage of 59.0%. They yielded 303.1 yards/game which ranked them 16th in Division 1. They conceded 16 touchdowns through the air as well as 13 touchdowns on the ground. They allowed teams to run for an average of 3.5 yards per run and 114.3 rushing yards per contest throughout last year. Overall, they allowed 1,486 rushing yards through 13 games. The Cardinals were sitting in 38th in the country when it comes to team defense, giving up 21.2 PPG.

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The Rebels finished the season holding a 13-2 record. The last time they took the field, the Rebels went home defeated by a final of 31-27 when they faced the Miami Hurricanes. Ole Miss ran for 5.8 yards per attempt, finishing the game with 121 yds on 21 attempts. The Rebels finished the contest with 398 yards on 60 plays (6.6 yards per play). The Rebels secondary allowed a completion rate of 62.2%, relinquishing 268 yds on 23 out of 37 through the air. Ole Miss conceded 51 rush attempts for 191 yds (3.7 yards per carry).

The Ole Miss Rebels held an average of 489.7 yards per outing, which had them sitting 2nd in Division 1. The Ole Miss offense accrued 786 yds of penalties on 83 violations, which ranked them 48th in the country in terms of giving up free yards. They averaged 176.3 yards per game via the ground game and rushed for 2,645 yards for the year. They gave away 8 interceptions while surrendering 6 fumbles and they obtained 383 first downs. In relation to how much they scored, the Rebels ranked 10th in college football holding an average of 36.9 points per game. For the previous year, the Rebels compiled 4,700 passing yards along with averaging 313.3 passing yards per game, which was ranked 3rd in Division 1.

The Rebels surrendered 21.1 PPG, ranking them 37th in college football. Ole Miss surrendered a total of 2,237 yards via the ground game (149.1 yards/game) as well as 20 touchdowns via the rush last year. They yielded 17 touchdowns via the pass as well as 198.9 yards per outing, which had them in 37th in the nation. The Rebels defense participated in 998 plays, which had them ranked 135th in Division 1. They tallied 6 fumbles and 9 interceptions last season. In total, they allowed 317 total points.

Who will win tonight's Cardinals/Rebels college football game against the spread?

Tony's Pick: Take the Rebels -7.5

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