LSU Tigers vs Ole Miss Rebels Prediction, 9/19/2026 College Football Picks, Best Bets & Odds

Game: LSU Tigers vs Ole Miss Rebels

Date: Saturday, September 19, 2026

Location: Vaught-Hemingway Stadium in Oxford, MS

TV: ESPN+

Odds/Point Spread: Rebels (+2.5)

Total/Over-Under: 57.5

Vaught-Hemingway Stadium is where the Ole Miss Rebels (2-0) will compete against the LSU Tigers (2-0) on Saturday, September 19, 2026. Ole Miss opens this contest as 2.5-point dogs from Vegas oddsmakers. The over/under has been set at 57.5.

The LSU Tigers come into this game with a record of 2-0 this year. In their last game, the Tigers stepped onto the field against the Louisiana Tech Bulldogs and earned the victory with a final of 45-14. In the game, they ran 84 plays which converted into 528 yds. The LSU Tigers ended up rushing 43 times and recorded 147 yards, which earned them an average of 3.4 yds per attempt. Against the run, the Tigers conceded -4 yards on 31 tries, which is an average of -0.1 yards per run surrendered. LSU relinquished 14 completions on 24 tries for a total of 143 yards, and a completion rate of 58.3%.

The Tigers have attained 1,172 total yards for the year. In terms of notching touchdowns, LSU has totaled 3 touchdowns through the air and 8 rushing touchdowns. They have surrendered the football 5 times. LSU has tallied 63 first downs as an offense, and they have committed 16 infractions for 176 yds. As a unit they average 228.0 yards via the ground game which is 27th in D-1. When it comes to getting in the endzone, the LSU Tigers have an average of 48.0 points per game.

When talking about yards through the air, the Tigers have allowed 248 yards which puts them in 11th in D-1. They have relinquished 124.0 yards per outing via the pass in addition to conceding a completion percentage of 60.9%. During this campaign, they are conceding 142.0 yards per game which puts them 1st in college football. They have yielded 1 touchdown through the air as well as 1 touchdown pounding the rock. They are giving up an average of 0.6 yards per running attempt and 18.0 rushing yards per game for the campaign. Over the course of this year, they have given up 36 running yards through 2 contests. The Tigers sit in 25th in D-1 when it comes to team defense, giving up 12.0 PPG.

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The Rebels come into this matchup with a record of 2-0 for this season. The last time they took the gridiron, the Rebels went home victorious with a score of 41-9 against the Charlotte 49ers. Ole Miss ran the football for 5.3 yds per carry, finishing with 127 yards on 24 carries. The Rebels finished the game with 420 yds on 58 plays (7.2 yds per play). The Rebels passing defense gave up a completion percentage of 71.4%, surrendering 179 yds on 20 for 28 passing. Ole Miss relinquished 33 rush attempts for 143 yds (4.3 yds per rush).

When it comes to how much they score, the Rebels currently sit 37th in college football scoring 41.0 PPG. The Ole Miss Rebels maintain an average of 454.0 yards per game, ranking them 39th in the country. The Ole Miss offense has 112 yards of penalties on 13 violations, which ranks them 71st in D-1 in terms of helping out the opposition. They have tossed 2 interceptions while letting opponents recover 1 fumble and they have tallied 49 1st downs. For the season so far, the Rebels currently have a total of 629 yards through the air not to mention an average of 314.5 passing yards per outing, which has them sitting 22nd in college football. They maintain an average of 139.5 run yards per game and have rushed for 279 yards overall.

The Rebels are giving up 23.5 points per contest, which has them 83rd in the country. Ole Miss has yielded a total of 305 yards rushing (152.5 yards per contest) and 2 touchdowns via the rush on the season. They have given up 2 touchdowns through the air in addition to 243.0 yards/outing, which has them ranked 106th in the country. The Rebels defense has been on the field for 129 plays, which ranks 69th in D-1. Their defense has compiled no fumbles recovered and 1 pick so far this year.

Who will win tonight's Tigers/Rebels college football game against the spread?

Josh's Pick: Take the Rebels +2.5

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