Missouri Tigers vs Mississippi State Bulldogs Prediction, 9/26/2026 College Football Picks, Best Bets & Odds

Game: Missouri Tigers vs Mississippi State Bulldogs

Date: Saturday, September 26, 2026

Location: Davis Wade Stadium in Starkville, MS

TV: SEC Network

Odds/Point Spread: Bulldogs (-6.5)

Total/Over-Under: 58.5

The Missouri Tigers (3-0) are hitting the road to Davis Wade Stadium on Saturday, September 26, 2026 where they will attempt to beat the Mississippi State Bulldogs (3-0). Mississippi State opens this game as 6.5-point favorites. The over/under is set at 58.5.

The Missouri Tigers head into this game 3-0 this season. The last time they stepped onto the field, the Tigers faced the Troy Trojans and notched a win by a score of 27-17. Once the final whistle blew, they had 47 plays which gave them 230 yds. The Missouri Tigers ended up rushing 28 different times and accounted for 139 yards, which had them averaging 5.0 yards per carry. When it came to stopping the run, the Tigers gave up 93 yards on 40 attempts, which is an average of 2.3 yds per run surrendered. Missouri allowed 18 pass completions on 32 tries for 230 yds, and a completion percentage of 56.3%.

Concerning putting points on the board, the Missouri Tigers are averaging 39.7 points per game. As a team they're averaging 173.7 yards rushing ranking this team at 57th in D-1. The Tigers have earned 1,261 total yards over the course of this year. When it comes to scoring touchdowns, Missouri has totaled 8 passing touchdowns and 6 touchdowns via the ground. Missouri has accumulated 67 first downs as a unit, and they have been hurt by 24 penalties for 201 yds. They have turned the ball over 2 times.

When talking about yards through the air, the Tigers have allowed 513 yards which ranks them 37th in D-1. They have conceded 171.0 yards per outing through the air as well as allowing a completion percentage of 49.3%. Over the course of this season, they have surrendered 258.3 yards per contest which has them sitting 22nd in the country. They have surrendered 5 touchdowns via the pass in addition to 1 touchdown via the ground game. They are allowing teams to run for an average of 2.5 yards per attempt on the ground and 87.3 rushing yards per contest for the season. During this campaign, they have given up 262 rushing yards through 3 games. The Tigers rank 41st in the nation when it comes to team defense, giving up 17.3 points per contest.

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The Bulldogs come into this game with a record of 3-0 this year. When they last stepped on the gridiron, the Bulldogs went home victorious with a score of 41-34 when they played the South Carolina Gamecocks. The Bulldogs finished the contest with a total of 393 yards and they ran 61 plays (6.4 yds per play). Mississippi State ran the ball for 4.0 yards per carry, finishing with 135 yards on 34 carries. Mississippi State surrendered 39 rushing attempts for 149 yds (3.8 yards per carry). The Bulldogs secondary gave up a completion percentage of 62.5%, relinquishing 282 yards on 25 for 40 through the air.

The Mississippi State Bulldogs have an average of 544.7 yards/contest, ranking them 2nd in D-1. The Mississippi State offense has totaled 236 yards of penalties on 28 infractions, which is 6th in the country in terms of making mistakes. They are averaging 244.0 yards via the ground game and have rushed for 732 yards for the year. They have tossed 1 interception while letting opponents recover 1 fumble and they have recorded 82 1st downs. When discussing their ability to score points, the Bulldogs are sitting 10th in the country holding an average of 47.0 points per game. During this campaign so far, the Bulldogs have thrown for a total of 902 yards via the pass along with holding an average of 300.7 passing yards per contest, ranking them 23rd in the country.

The Bulldogs are allowing 20.0 points per game, which has them sitting 59th in Division 1. Mississippi State has allowed a total of 300 yards rushing (100.0 yards per contest) as well as 1 touchdown via the rush this year. They have allowed the opposition 3 touchdowns via the pass and 233.7 yards/outing, which has them ranked 100th in D-1. The Bulldogs defense has been on the field for 210 plays, which ranks 106th in college football. They have compiled no fumbles and 2 interceptions so far this year. This season, they have relinquished 60 total points.

Who will win tonight's Tigers/Bulldogs college football game against the spread?

Guy's Pick: Take the Tigers +6.5

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