Northwestern Wildcats vs Indiana Hoosiers Prediction, 9/25/2026 College Football Picks, Best Bets & Odds

Game: Northwestern Wildcats vs Indiana Hoosiers

Date: Friday, September 25, 2026

Location: Memorial Stadium in Bloomington, IN

TV: FOX

Odds/Point Spread: Hoosiers (-21.5)

Total/Over-Under: 49

Memorial Stadium is the site where the Indiana Hoosiers (3-0) will play the Northwestern Wildcats (2-0) on Friday, September 25, 2026. Indiana opens as 21.5-point favorites from Vegas oddsmakers. The total has been set at 49.

The Northwestern Wildcats head into this game 2-0 this season. In their last game, the Wildcats took on the Colorado Buffaloes and notched a win by a score of 41-7. Overall, they had 73 plays for 423 yds. The Northwestern Wildcats ended up running the ball 51 different times and accrued 182 yards, which had them averaging 3.6 yds per carry. Against the run, the Wildcats gave up 180 yds on 33 tries, which is 5.5 yds per rush surrendered. Northwestern surrendered 19 pass completions on 29 attempts for 168 yds, and a completion percentage of 65.5%.

Concerning getting in the endzone, the Northwestern Wildcats are sitting at 37.5 points per outing. As a unit they are averaging 203.0 yards on the ground which has them sitting 41st in the nation. The Wildcats have tallied 920 total yards for the year. When it comes to distribution of touchdowns, Northwestern has amassed 4 touchdowns through the air and 5 rushing touchdowns. Northwestern has tallied 40 1st downs, and they have committed 17 infractions for 121 yards. They have turned the ball over 1 time.

The Wildcats are sitting in 20th in college football concerning the opposition scoring, giving up 12.5 points per game. The opposition is running for 4.5 yards per rushing attempt and 163.5 rushing yards per game for the season. For the year, they have allowed 327 running yards through 2 games. Concerning yards through the air, the Wildcats have allowed 453 yds which has them ranked 20th in D-1. They have conceded 226.5 yards per outing through the air in addition to conceding a completion percentage of 54.5%. Over the course of this year, they are allowing 390.0 yards/contest which puts them 106th in D-1. They have surrendered 1 touchdown via the pass as well as 1 touchdown via the ground game.

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The Hoosiers step onto the field holding a record of 3-0 this year. When they last played, the Hoosiers walked away with a victory by a final of 38-0 against the Western Kentucky Hilltoppers. The Hoosiers finished the game with 513 yards while running 66 plays (7.8 yards per play). Indiana ran the ball for 5.7 yards per tote, finishing with a total of 233 yards on 41 attempts. Indiana conceded 29 running attempts for 66 yards (2.3 yds per rush). The Hoosiers secondary conceded a completion percentage of 53.1%, surrendering 120 yds on 17 out of 32 through the air.

The Indiana Hoosiers are averaging 461.0 yards per game, which ranks them 37th in the nation. The Indiana offense has accrued 78 penalty yards on 9 infractions, which is good for 134th in Division 1 in terms of helping out the opposition. They maintain an average of 221.0 yards per game via the ground game and have rushed for 663 yards for this year. They have tossed no interceptions while letting opponents recover 1 fumble and they have been able to earn 66 1st downs. When looking at their scoring prowess, the Hoosiers rank 6th in the nation averaging 48.3 points per contest. During this campaign to this point, the Hoosiers have compiled 720 yards via the pass in addition to holding an average of 240.0 passing yards per game, which has them ranked 62nd in the country.

Indiana has conceded a total of 231 rushing yards (77.0 yards per contest) and 1 touchdown via the rush on the year. They have surrendered 0 touchdowns via the pass as well as 126.3 yards per game, which has them in 11th in D-1. In total, they have conceded 16 pts. They have totaled no fumbles recovered and 3 picks this season. The Hoosiers defense has been on the field for 175 plays, which ranks 26th in D-1. The Hoosiers are relinquishing 5.3 PPG, which has them ranked 2nd in college football.

Who will win tonight's Wildcats/Hoosiers college football game against the spread?

Parlays Pundit's Pick: Take the Hoosiers -21.5

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