Ohio State Buckeyes vs Indiana Hoosiers Prediction, 10/17/2026 College Football Picks, Best Bets & Odds

Game: Ohio State Buckeyes vs Indiana Hoosiers

Date: Saturday, October 17, 2026

Location: Memorial Stadium in Bloomington, IN

TV: FOX

Odds/Point Spread: Hoosiers (+3.5)

Total/Over-Under: 50.5

The Indiana Hoosiers (6-0) will take on the Ohio State Buckeyes (5-1) at Memorial Stadium on Saturday, October 17, 2026. Ohio State opens this game as 3.5-point favorites. The over/under has been set at 50.5.

The Ohio State Buckeyes head into this game 5-1 this season. In their last game, the Buckeyes went up against the Maryland Terrapins and went home with a win by a final score of 45-16. On the ground, the Buckeyes gave up 82 yds on 28 attempts, which averages out to 2.9 yds per rush allowed. Ohio State relinquished 12 completions on 25 attempts for a total of 64 yards, and a completion rate of 48.0%. Overall, they tallied 69 plays for 449 yards. The Ohio State Buckeyes ran the ball a total of 48 different times and amassed 207 yds, which is an average of 4.3 yards per tote.

Concerning getting in the endzone, the Ohio State Buckeyes hold an average of 42.7 points per game. Offensively they're averaging 165.7 yards in the run game giving them a rank of 60th in D-1. The Buckeyes have racked up 3,021 total yards for the season. When it comes to scoring, Ohio State has compiled 20 touchdowns through the air and 13 touchdowns via the ground. Ohio State has recorded 152 1st downs as a team, and they have been hurt by 40 infractions for 314 yards. They have surrendered the football 6 different times.

The Buckeyes rank 8th in the nation regarding team defense, conceding 13.2 points per contest. Opposing teams are running for an average of 3.2 yards per attempt on the ground and 96.2 rushing yards per game on the campaign. During the season, they have conceded 577 yards via the running game in 6 games. When talking about passing yards, the Buckeyes have conceded 904 yds which puts them in 23rd in the nation. They have relinquished 150.7 yards per outing through the air and allowed a completion percentage of 53.0%. Over the course of this year, they have surrendered 246.8 yards per contest which puts them 5th in the nation. They have yielded 2 touchdowns by air as well as 5 touchdowns running the ball.

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The Hoosiers head into this matchup 6-0 for this season. The last time they took the field, the Hoosiers took home the win by a final score of 20-17 against the Nebraska Cornhuskers. Indiana surrendered 39 running attempts for 128 yds (3.3 yds per carry). The Hoosiers pass defense allowed a completion percentage of 56.8%, surrendering 264 yds on 25 for 44 passing. The Hoosiers finished the game with a total of 328 yds while running 44 plays (7.5 yards per play). Indiana ran the ball for 3.0 yards per tote, finishing with a total of 65 yds on 22 carries.

The Indiana Hoosiers hold an average of 462.7 yards per outing, which has them ranked 20th in Division 1. The Indiana offense has 173 penalty yds on 20 violations, which is 135th in college football in terms of hurting your team. They hold an average of 221.3 yards per game on the ground and have rushed for 1,328 yards in total. They have tossed 0 interceptions while surrendering 1 fumble and they have been able to earn 129 first downs. When it comes to their scoring prowess, the Hoosiers rank 14th in the country maintaining an average of 40.2 points per game. Over the course of the season thus far, the Hoosiers currently sit at 1,448 yards via the pass in addition to holding an average of 241.3 passing yards per outing, putting them at 60th in D-1.

Indiana has allowed the opposition a total of 450 yards rushing (75.0 yards per outing) and 5 touchdowns by way of the ground game on the campaign. They have conceded 3 touchdowns from the passing game as well as 188.5 yards/game, which has them in 41st in Division 1. Overall, they have surrendered 71 points in total. They have no fumbles and 4 picks this season. The Hoosiers defense has been on the field for 370 plays, which ranks them 72nd in college football. The Hoosiers are allowing 11.8 points per contest, which has them 5th in D-1.

Who will win tonight's Buckeyes/Hoosiers college football game against the spread?

Guy's Pick: Take the Hoosiers +3.5

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