Oregon Ducks vs USC Trojans Prediction, 9/26/2026 College Football Picks, Best Bets & Odds

Game: Oregon Ducks vs USC Trojans

Date: Saturday, September 26, 2026

Location: Los Angeles Memorial Coliseum in Los Angeles, CA

TV: NBC

Odds/Point Spread: Trojans (+2.5)

Total/Over-Under: 62

Los Angeles Memorial Coliseum is the site where the USC Trojans (4-0) will try to beat the Oregon Ducks (2-1) on Saturday, September 26, 2026. Oregon opens this contest as 2.5-point favorites. The over/under comes in at 62.

The Oregon Ducks come into this matchup with a record of 2-1 this season. In their last matchup, the Ducks took the field against the Portland State Vikings and walked away with a win by a score of 84-0. In the running game, the Ducks conceded 2 yds on 17 attempts, which is an average of 0.1 yards per rush surrendered. Oregon surrendered 8 completions on 20 attempts for a total of 101 yards, and a completion rate of 40.0%. At the end of the game, they ran 94 plays which totaled 740 yds. The Oregon Ducks ended up rushing 51 times and totaled 289 yards, which had them averaging 5.7 yds per attempt.

When it comes to getting in the endzone, the Oregon Ducks are averaging 49.7 PPG. Offensively they hold an average of 166.0 yards on the ground which ranks them 67th in the nation. The Ducks have earned 1,518 total yards for the year. In terms of getting in the endzone, Oregon has compiled 12 touchdowns through the air and 7 rushing touchdowns. Oregon has amassed 73 1st downs, and they have committed 24 infractions for 221 yds. They have surrendered the ball 2 different times.

Concerning yards through the air, the Ducks have conceded 599 yds which has them sitting in 67th in college football. They have relinquished 199.7 yards per outing through the air and conceding a completion percentage of 53.1%. Over the course of this year, they are conceding 310.3 yards per contest which puts them 55th in the nation. They have allowed 5 touchdowns via the pass as well as 2 touchdowns on the ground. The opposition is running for 3.6 yards per run and 110.7 rushing yards per game for the campaign. In total, they have given up 332 running yards through 3 games. The Ducks rank 70th in the country when it comes to the opposition scoring, conceding 22.0 points per game.

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The Trojans step onto the field holding a record of 4-0 for this year. When they last stepped on the field, the Trojans got the victory with a final of 42-35 against the Rutgers Scarlet Knights. USC ran the football for 5.9 yards per tote, finishing the game with 184 yards on 31 attempts. The Trojans finished the contest with 461 yds while running 63 plays (7.3 yards per play). The Trojans pass defense gave up a completion rate of 51.4%, surrendering 292 yards on 19 out of 37 through the air. USC gave up 32 running attempts for 168 yards (5.3 yards per carry).

The USC Trojans are averaging 500.3 yards per contest, which is good for 19th in college football. The USC offense has totaled 227 yds of penalties on 26 violations, which ranks them 23rd in the country in terms of giving up free yards. They maintain an average of 175.5 rushing yards per game and have rushed for 702 yards for the season. They have given away 2 interceptions while letting opponents recover 2 fumbles and they have obtained 105 first downs. Regarding their scoring prowess, the Trojans currently sit 21st in Division 1 with an average of 43.0 PPG. For the year so far, the Trojans currently sit at 1,299 yards through the air along with an average of 324.8 passing yards per game, which is ranked 12th in D-1.

The Trojans are allowing 22.8 PPG, ranking them 73rd in Division 1. USC has conceded a total of 455 yards on the ground (113.8 yards per contest) and 6 touchdowns by way of the ground game on the year. They have conceded 6 touchdowns from the passing game and 203.8 yards per outing, which has them in 70th in the country. The Trojans defense has taken part in 221 plays, which is 125th in Division 1. They have 1 fumble and 3 interceptions for the season. This year, they have conceded 91 total points.

Who will win tonight's Ducks/Trojans college football game against the spread?

Guy's Pick: Take the Ducks -2.5

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