Stanford Cardinal vs Duke Blue Devils Prediction, 9/19/2026 College Football Picks, Best Bets & Odds

Game: Stanford Cardinal vs Duke Blue Devils

Date: Saturday, September 19, 2026

Location: Wallace Wade Stadium in Durham, NC

TV: ESPN+

Odds/Point Spread: Blue Devils (-9.5)

Total/Over-Under: 50.5

Wallace Wade Stadium is the site where the Duke Blue Devils (2-0) will attempt to beat the Stanford Cardinal (1-1) on Saturday, September 19, 2026. Stanford is 9.5-point underdogs from oddsmakers. The over/under is set at 50.5.

The Stanford Cardinal head into this matchup 1-1 for this season. The last time they took the field, the Cardinal went up against the Miami Hurricanes and took a loss by a score of 45-6. The Stanford Cardinal ran the ball 23 different times and accrued 78 yds, earning them an average of 3.4 yards per tote. In all, they had 65 plays which converted into 299 yards. Stanford relinquished 30 completions on 35 tries for 428 yards, and a completion percentage of 85.7%. On the ground, the Cardinal conceded 121 yds on 32 attempts, which averages out to 3.8 yds per rush allowed.

In terms of putting the ball in the endzone, the Stanford Cardinal are averaging 21.5 points per outing. Offensively they average 118.0 yards rushing which has them sitting 113th in college football. The Cardinal currently have 767 total yards over the course of this year. When it comes to scoring touchdowns, Stanford has compiled 1 touchdown through the air and 3 touchdowns on the ground. Stanford has earned 38 1st downs as an offense, and they have committed 17 penalties for 129 yds. They have yet to turn the ball over.

Regarding passing yardage, the Cardinal have allowed 707 yds which has them sitting in 133rd in the country. They have conceded 353.5 yards per outing through the air and allowed a completion percentage of 70.5%. Over the course of this year, they have given up 437.0 yards per contest which ranks them 122nd in the nation. They have allowed 7 touchdowns by air as well as 3 touchdowns pounding the rock. The opposition is running for an average of 3.1 yards per rushing attempt and 83.5 rushing yards per game this season. For the season, they have given up 167 rushing yards through 2 outings. The Cardinal are sitting in 129th in college football concerning their opponents scoring, giving up 36.0 PPG.

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The Blue Devils step onto the field holding a record of 2-0 this year. In their last game, the Blue Devils walked away with a victory by a final of 31-27 when they faced the Illinois Fighting Illini. Duke gave up 32 running attempts for 111 yds (3.5 yds per rush). The Blue Devils passing defense gave up a completion rate of 66.7%, surrendering 271 yards on 24 for 36 passing. The Blue Devils finished the contest with 376 yds and they ran 57 plays (6.6 yards per play). Duke ended up running for 4.9 yds per carry, finishing with a total of 170 yds on 35 attempts.

In relation to their ability to score points, the Blue Devils are ranking 101st in D-1 by scoring 24.0 points per game. The Duke Blue Devils average 378.5 yards/game, which is good for 88th in the nation. The Duke offense has racked up 165 penalty yards on 19 violations, which is good for 14th in the nation in terms of helping out the other team. They have thrown no interceptions while losing 1 fumble and they have recorded 39 first downs. During this campaign thus far, the Blue Devils have thrown for a total of 337 yards through the air not to mention holding an average of 168.5 passing yards per game, which has them sitting 113th in the nation. They hold an average of 210.0 yards per game via the rush and have toted the ball for 420 yards in total.

Duke has allowed the opposition a total of 165 yards on the ground (82.5 yards per contest) in addition to 0 touchdown by way of the ground game on the season. They have allowed the opposition 3 touchdowns via the pass as well as 237.5 yards per outing, which puts them in 101st in Division 1. Their defense has tallied 1 fumble and 1 interception this year. The Blue Devils defense has been on the field for 124 plays, ranking them 57th in Division 1. The Blue Devils are conceding 15.0 points per game, which puts them 43rd in college football.

Who will win tonight's Cardinal/Blue Devils college football game against the spread?

Guy's Pick: Take the Blue Devils -9.5

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