Stanford Cardinal vs Louisville Cardinals Prediction, 10/31/2026 College Football Picks, Best Bets & Odds

Game: Stanford Cardinal vs Louisville Cardinals

Date: Saturday, October 31, 2026

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ACC Network

Odds/Point Spread: Cardinals (-23.5)

Total/Over-Under: 61.5

The Louisville Cardinals (4-3) will compete against the Stanford Cardinal (4-4) at L&N Federal Credit Union Stadium on Saturday, October 31, 2026. Stanford opens this contest as 23.5-point underdogs. The over/under has been set at 61.5.

The Stanford Cardinal head into this game 4-4 for this season. The last time they stepped onto the field, the Cardinal took the field against the NC State Wolfpack and went home with a win by a final score of 31-28. The Stanford Cardinal ran the ball a total of 33 times and amassed 174 yards, earning them an average of 5.3 yards per carry. In all, they tallied 70 plays which gave them 477 yards. Stanford relinquished 17 completions on 31 attempts for 256 yards, and a completion percentage of 54.8%. On the ground, the Cardinal conceded 125 yards on 33 attempts, which is an average of 3.8 yards per rush surrendered.

Concerning scoring, the Stanford Cardinal have an average of 19.9 points per game. As a team they hold an average of 112.3 yards rushing which has them sitting 121st in Division 1. The Cardinal have racked up 2,877 yards in total this year. When it comes to getting in the endzone, Stanford has earned 11 passing touchdowns and 8 rushing touchdowns. Stanford has accrued 151 first downs, and they have been called for 54 infractions for 463 yards. They have turned the ball over 6 times.

When it comes to passing yardage, the Cardinal have given up 2,044 yds which puts them in 132nd in college football. They have relinquished 255.5 yards per game through the air in addition to conceding a completion percentage of 63.1%. Overall, they are allowing 443.1 yards per outing which ranks them 133rd in the nation. They have yielded 17 touchdowns via the pass and 22 touchdowns on the ground. They are allowing teams to run for an average of 5.3 yards per attempt on the ground and 187.6 rushing yards per game on the campaign. For the year, they have given up 1,501 yards via the ground game in 8 games. The Cardinal rank 132nd in the nation when it comes to their opponents scoring, allowing 35.5 PPG.

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The Cardinals head into this game 4-3 for this season. The last time they took the field, the Cardinals walked away with a victory by a final of 34-26 against the Syracuse Orange. Louisville ran for 3.3 yards per tote, finishing with a total of 115 yards on 35 attempts. The Cardinals finished the game with 425 yds while they ran 61 plays (7.0 yds per play). The Cardinals pass defense conceded a completion rate of 65.9%, surrendering 339 yards on 29 for 44 through the air. Louisville relinquished 39 running attempts for 123 yds (3.2 yards per rush).

When it comes to putting points on the board, the Cardinals rank 11th in the nation scoring 38.7 points per game. The Louisville Cardinals maintain an average of 484.6 yards per contest, which ranks them 8th in the nation. The Louisville offense has accrued 537 yds of penalties on 53 infractions, ranking them 40th in Division 1 in terms of helping out the opposition. They have given away 3 picks while surrendering 3 fumbles and they have been able to earn 153 1st downs. During this campaign thus far, the Cardinals have thrown for a total of 1,887 yards via the pass not to mention an average of 269.6 throwing yards per contest, giving them a rank of 29th in D-1. They hold an average of 215.0 yards per game on the ground and have toted the ball for 1,505 yards in total.

Louisville has given up a total of 1,057 yards via the ground game (151.0 yards per game) in addition to 10 touchdowns by way of the ground game for the campaign. They have allowed the opposition 12 touchdowns from the passing game in addition to 268.9 yards/game, which puts them in 129th in college football. Over the course of the season, they have surrendered 192 pts. They have tallied 5 fumbles and 7 picks this season. The Cardinals defense has participated in 525 plays, which ranks 121st in the country. The Cardinals are giving up 27.4 points per game, which has them sitting 99th in college football.

Who will win tonight's Cardinal/Cardinals college football game against the spread?

Guy's Pick: Take the Cardinals -23.5

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