Virginia Tech Hokies vs SMU Mustangs Prediction, 11/6/2026 College Football Picks, Best Bets & Odds

Game: Virginia Tech Hokies vs SMU Mustangs

Date: Friday, November 6, 2026

Location: Gerald J. Ford Stadium in Dallas, TX

TV: ESPN

Odds/Point Spread: Mustangs (-6.5)

Total/Over-Under: 55

The SMU Mustangs (6-2) welcome the Virginia Tech Hokies (6-2) at Gerald J. Ford Stadium on Friday, November 6, 2026. Virginia Tech is 6.5-point dogs from oddsmakers. The total is 55.

The Virginia Tech Hokies step onto the field holding a record of 6-2 for this season. In their last contest, the Hokies played the Clemson Tigers and walked away with a win by a score of 20-16. Once the final whistle blew, they tallied 70 plays which gave them a total of 234 yards. The Virginia Tech Hokies ran the ball a total of 37 times and accumulated 70 yds, which earned them an average of 1.9 yards per tote. When it came to stopping the run, the Hokies conceded 135 yds on 36 attempts, which averages out to 3.8 yds per run surrendered. Virginia Tech relinquished 20 completions on 26 attempts for a total of 153 yards, and a completion rate of 76.9%.

When it comes to putting points on the board, the Virginia Tech Hokies are averaging 35.0 PPG. Offensively they're averaging 139.8 yards via the ground game ranking them 95th in college football. The Hokies have earned 3,393 total yards this season. With reference to getting in the endzone, Virginia Tech has compiled 18 touchdowns through the air and 15 rushing touchdowns. Virginia Tech has tallied 188 first downs, and they have been called for 54 infractions for 496 yards. They have turned the football over 10 times.

The Hokies rank 37th in the nation concerning team defense, giving up 20.5 points per game. They are allowing teams to run for an average of 3.0 yards per rushing attempt and 93.4 rushing yards per contest so far this year. In total, they have given up 747 rushing yards through 8 games. In terms of yards through the air, the Hokies have given up 1,744 yds which has them sitting in 72nd in D-1. They have surrendered 218.0 yards per outing through the air and conceding a completion percentage of 65.1%. For the year, they are surrendering 311.4 yards per game ranking them 27th in the country. They have yielded 9 touchdowns via the pass as well as 11 touchdowns on the ground.

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The Mustangs head into this matchup 6-2 for this season. For their last game, the Mustangs took a loss by a final score of 30-27 when they played the Syracuse Orange. SMU rushed for 2.2 yds per attempt, finishing the contest with 69 yds on 31 attempts. The Mustangs finished with 421 yds and they ran 68 plays (6.2 yds per play). The Mustangs pass defense allowed a completion percentage of 61.8%, surrendering 200 yards on 21 out of 34 passing. SMU allowed 37 rush attempts for 138 yards (3.7 yards per carry).

Regarding how much they score, the Mustangs rank 26th in Division 1 holding an average of 35.3 PPG. The SMU Mustangs maintain an average of 464.1 yards per game, which has them sitting 15th in D-1. The SMU offense has accrued 554 penalty yds on 59 violations, which is good for 39th in the country in terms of giving up free yards. They have thrown 5 interceptions while letting opponents recover 6 fumbles and they have been able to obtain 198 1st downs. For the year thus far, the Mustangs have a total of 2,544 passing yards as well as holding an average of 318.0 passing yards per outing, ranking them 8th in the country. They have an average of 146.1 yards per game via the rush and have toted the ball for 1,169 yards for the season.

SMU has conceded a total of 1,007 yards rushing (125.9 yards/game) as well as 10 touchdowns on the ground so far this year. They have allowed the opposition 10 touchdowns via the pass and 181.8 yards/contest, which has them sitting 28th in the country. In total, they have relinquished 178 points in total. Their defense has tallied 4 fumbles recovered and 2 picks on the season. The Mustangs defense has taken the field for 506 plays, which ranks them 43rd in D-1. The Mustangs are conceding 22.3 PPG, which has them ranked 53rd in college football.

Who will win tonight's Hokies/Mustangs college football game against the spread?

Guy's Pick: Take the Mustangs -6.5

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