Western Kentucky Hilltoppers vs Indiana Hoosiers Prediction, 9/19/2026 College Football Picks, Best Bets & Odds

Game: Western Kentucky Hilltoppers vs Indiana Hoosiers

Date: Saturday, September 19, 2026

Location: Memorial Stadium in Bloomington, IN

TV: Peacock

Odds/Point Spread: Hoosiers (-45.0)

Total/Over-Under: 59.5

Memorial Stadium is where the Indiana Hoosiers (2-0) will play the Western Kentucky Hilltoppers (0-2) on Saturday, September 19, 2026. Western Kentucky opens as 45-point underdogs from oddsmakers. The over/under comes in at 59.5.

The Western Kentucky Hilltoppers step onto the field holding a record of 0-2 this season. The last time they took the field, the Hilltoppers stepped onto the field against the Georgia Bulldogs and went home with a loss by a final score of 70-20. The Western Kentucky Hilltoppers ran the rock 37 times and had 110 yds, which came out to an average of 3.0 yards per attempt. In the game, they had 74 plays which gave them a total of 225 yds. Western Kentucky gave up 16 completions on 25 attempts for a total of 259 yds, and a completion rate of 64.0%. In the running game, the Hilltoppers gave up 234 yds on 35 tries, which averages out to 6.7 yds per rush allowed.

Regarding scoring, the Western Kentucky Hilltoppers are averaging 17.0 points per game. Offensively they're averaging 137.0 yards via the ground game ranking this team at 97th in D-1. The Hilltoppers have racked up 592 total yards over the course of this season. When it comes to scoring touchdowns, Western Kentucky has totaled 1 touchdown through the air and 4 rushing touchdowns. Western Kentucky has recorded 40 1st downs as a team, and they have been called for 12 penalties for 99 yds. They have turned the ball over 6 times.

Regarding yards through the air, the Hilltoppers have allowed 422 yds which ranks them 76th in Division 1. They have allowed 211.0 yards per contest through the air in addition to allowing a completion percentage of 61.0%. Over the course of this season, they are conceding 489.5 yards per game which has them sitting 132nd in college football. They have yielded 7 touchdowns via the pass and 8 touchdowns pounding the rock. They are allowing 7.2 yards per tote and 278.5 rushing yards per game so far this year. Overall, they have conceded 557 rushing yards through 2 outings. The Hilltoppers are sitting in 138th in the nation when it comes to team defense, allowing 59.5 points per game.

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The Hoosiers head into this matchup 2-0 for this season. In their last game, the Hoosiers got the victory with a final of 55-0 when they faced the Howard Bison. The Hoosiers ended up finishing with 510 yards while running 62 plays (8.2 yards per play). Indiana rushed for 6.5 yds per attempt, totaling 301 yds on 46 attempts. Indiana surrendered 27 rushing attempts for 13 yards (0.5 yds per carry). The Hoosiers passing defense gave up a completion percentage of 50.0%, surrendering 44 yds on 10 for 20 through the air.

The Indiana Hoosiers average 437.5 yards/game, which has them ranked 49th in college football. The Indiana offense has totaled 63 yds of penalties on 7 violations, which is 124th in the nation in terms of helping out the opposition. They have an average of 217.5 yards per game on the ground and have run for 435 yards for the season. They have given away no picks while conceding 1 fumble and they have been able to obtain 42 1st downs. Regarding the points being put on the board, the Hoosiers are sitting 8th in the nation maintaining an average of 53.5 PPG. For the year to this point, the Hoosiers have thrown for a total of 440 yards through the air as well as holding an average of 220.0 passing yards per game, ranking them 78th in college football.

Indiana has allowed the opposition a total of 165 yards via the ground game (82.5 yards/game) as well as 1 touchdown by way of the ground game on the campaign. They have surrendered no TD's via the pass and 129.5 yards/game, which puts them in 16th in college football. They have earned no fumbles and 2 picks on the season. The Hoosiers defense has taken the field for 114 plays, which is 28th in D-1. The Hoosiers are surrendering 8.0 PPG, which has them sitting 11th in Division 1.

Who will win tonight's Hilltoppers/Hoosiers college football game against the spread?

Josh's Pick: Take the Hilltoppers +45.0

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