Wyoming Cowboys vs North Dakota State Bison Prediction, 10/3/2026 College Football Picks, Best Bets & Odds

Game: Wyoming Cowboys vs North Dakota State Bison

Date: Saturday, October 3, 2026

Location: Fargodome in Fargo, ND

TV: ESPN+

Odds/Point Spread: Bison (-19.0)

Total/Over-Under: 45.5

Fargodome is the site where the North Dakota State Bison (4-0) will go up against the Wyoming Cowboys (2-2) on Saturday, October 3, 2026. North Dakota State is 19-point favorites from Vegas oddsmakers. The total comes in at 45.5.

The Wyoming Cowboys step onto the field holding a record of 2-2 for this year. In their last game, the Cowboys stepped onto the field against the Hawaii Warriors and notched a win by a score of 27-10. On the day, they had 61 plays which totaled 387 yards. The Wyoming Cowboys ran the ball a total of 38 times and had 183 yds, earning them an average of 4.8 yards per tote. Against the run, the Cowboys gave up 102 yards on 23 tries, which averages out to 4.4 yards per run surrendered. Wyoming surrendered 28 completions on 44 attempts for a total of 226 yds, and a completion percentage of 63.6%.

The Cowboys currently have 1,304 total yards this season. When it comes to scoring touchdowns, Wyoming has totaled 2 passing touchdowns and 6 rushing touchdowns. They have surrendered the football 8 times. Wyoming has 73 first downs as an offense, and they have committed 23 infractions for 194 yds. As a unit they average 160.3 yards via the ground game ranking this team at 70th in the country. In terms of scoring points, the Wyoming Cowboys are averaging 17.8 points per contest.

The Cowboys are ranked 50th in Division 1 in terms of their opponents scoring, conceding 20.5 points per game. They are allowing an average of 4.9 yards per rushing attempt and 183.5 rushing yards per game for the year. Overall, they have given up 734 yards via the running game in 4 contests. Concerning yards through the air, the Cowboys have allowed 706 yards which has them ranked 39th in the country. They have surrendered 176.5 yards per outing through the air as well as allowing a completion percentage of 62.9%. Overall, they are conceding 360.0 yards per contest which ranks them 79th in the country. They have granted 7 touchdowns by air in addition to 3 touchdowns running the ball.

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The Bison head into this game 4-0 this season. The last time they took the field, the Bison walked away with a victory by a final of 31-10 when they played the Sacramento State Hornets. North Dakota State gave up 26 run attempts for 90 yds (3.5 yds per rush). The Bison pass defense allowed a completion rate of 62.5%, surrendering 240 yards on 25 for 40 through the air. The Bison finished the game with 362 yds while they ran 59 plays (6.1 yds per play). North Dakota State rushed the football for 4.5 yds per attempt, finishing with a total of 152 yards on 34 attempts.

In terms of the points being put on the board, the Bison are 47th in D-1 averaging 35.0 PPG. The North Dakota State Bison maintain an average of 370.5 yards per contest, which has them ranked 89th in the nation. The North Dakota State offense has accrued 244 yds of penalties on 28 infractions, which has them ranked 55th in D-1 in terms of hurting your team. They have thrown 2 interceptions while surrendering no fumbles and they have been able to earn 76 first downs. For the season thus far, the Bison have a total of 847 yards through the air as well as an average of 211.8 throwing yards per outing, giving them a rank of 88th in D-1. They maintain an average of 158.8 yards per game via the rush and have run for 635 yards in total.

The Bison are giving up 12.3 PPG, which puts them 12th in the country. North Dakota State has allowed the opposition a total of 401 rushing yards (100.3 yards/game) in addition to 3 touchdowns via the rush so far this year. They have given up 3 touchdowns through the air and 154.5 yards/contest, which has them in 14th in Division 1. The Bison defense has been on the field for 234 plays, which ranks them 29th in the country. Their defense has compiled 3 fumbles and 7 picks for the season. This year, they have relinquished 49 points in total.

Who will win tonight's Cowboys/Bison college football game against the spread?

Guy's Pick: Take the Bison -19.0

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