Cleveland Cavaliers vs New York Knicks Prediction, 10/22/2025 Preview and Pick

Game: Cleveland Cavaliers vs New York Knicks

Date: Wednesday, October 22, 2025

Location: Madison Square Garden in New York, NY

TV: ESPN

Odds/Point Spread: Cleveland (+2.5)

The New York Knicks (51-31 last season) will take on the Cleveland Cavaliers (64-18 last year) at Madison Square Garden on Wednesday. Cleveland opens this contest as 2.5-point dogs. The over/under is 228.5.

The Cavaliers took the court against the Pacers and took a loss by a final of 114-105 in their last contest. When talking about personal fouls, the Cavaliers walked away with 23 and the Pacers finished the game with 27 personal fouls. They also buried 15 of 35 attempts from three-point range. Indiana ended up shooting 77.3% from the free throw line by burying 17 of their 22 attempts. Moreover, Indiana pulled down 47 rebounds (5 offensive, 42 defensive) and added 3 rejections. Indiana earned 26 assists and had 8 steals for this game. With respect to defense, Cleveland let their opponent shoot 50.0% from the floor on 41 of 82 shooting. They also doled out 10 assists for the matchup while forcing the opposition into 14 turnovers and getting 8 steals. With respect to rebounding, they earned 46 with 15 of them being on the offensive end. At the free throw line, the Cavaliers knocked down 26 of 37 attempts for a rate of 70.3%. Cleveland ended the game having earned a 38.9% FG percentage (35 of 90) and buried 9 out of their 35 shots from beyond the arc.

Donovan Mitchell is one player who had an impact in this contest. He ended up scoring 35 points on 8 out of 25 shooting. He was on the court for 38 mins played and also pulled down 9 rebounds. Mitchell finished 32.0% from the floor and distributed 1 assist.

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Cleveland heads into this one after finishing with a win-loss record of 64-18 last year. They turned it over 13.2 times per contest and as a group committed 18.1 fouls on a nightly basis. As a basketball team, Cleveland collected 45.4 rebounds per contest and totaled 2,304 dimes last season, which ranked 9th in basketball in terms of passing the ball. The Cavaliers shot 38.3% on shots from 3-point land (1,303 of 3,401) and 77.6% from the free throw line. They had an average of 121.9 points per game (1st in the NBA) while going 49.1% from the floor.

On the defensive end of the court, the Cavaliers forced their opponents into 14.5 turnovers per contest while drawing 18.9 personal fouls. They were 8th in the league in giving up assists with 2,101 relinquished last season. The Cavaliers defense allowed a FG percentage of 45.4% (3,382 of 7,454) and they surrendered 43.5 boards per contest as a group. They relinquished 35.9% on shots from beyond the perimeter while they were 12th in the NBA in opponents points per game (112.4).

When they last stepped on the hardwood, the Knicks went home defeated by a final of 125-108 against the Pacers. The Knicks snagged 28 defensive rebounds and 13 offensive boards for a total of 41 in the game. They also turned it over 18 times, while earning 10 steals for this contest. The Pacers earned 2 fouls for this game which got the Knicks to the free throw line for a total of 26 attempts. They were able to convert 17 of the free throw attempts for a percentage of 65.4%. With respect to shooting from downtown, New York buried 9 out of their 32 tries (28.1%). When this game wrapped up, the Knicks finished 41 out of 86 from the floor which gave them a rate of 47.7%. The Knicks permitted the Pacers to bury 46 out of their 85 tries from the floor which gave them a shooting percentage of 54.1% in this matchup. They finished 51.5% from distance by connecting on 17 out of 33 and walked away from this one shooting 16 of 19 from the charity stripe (84.2%). With respect to how they rebounded, New York allowed Indiana to grab 36 overall (6 offensive).

OG Anunoby pitched in for the Knicks in the game. He made 10 of 18 in the game for a field goal rate of 55.6%, and had 5 rebounds. Anunoby earned 24 points in his 37 mins of playing time and totaled 3 assists for this contest.

New York had a record of 51-31 last season. The Knicks were responsible for committing 17.2 fouls every game and they shot 80.0% from the charity stripe. They got an assist 27.5 times per contest (11th in the league) and they coughed up possession 13.3 times per game. New York scored 9,494 points last year (115.8 per game) and they pulled down 42.6 rebounds per game. As an offense, the Knicks shot 48.6% from the floor, which was ranked 5th in the NBA.

The Knicks on the defensive side of the court were 9th in the NBA in PPG surrendered with 111.7. They forced 14.5 TO's every game and allowed teams to shoot 47.4% from the field (25th in the league). The New York defense allowed 36.7% on 3-pointers (1,072 of 2,924) and opponents knocked down 78.9% of their shots from the charity stripe. They allowed 25.2 assists and 41.8 boards every game, which ranked them 7th and 2nd in basketball.

Who will win tonight's NBA game against the spread?

Tony Sink's Pick: Take Cleveland (+2.5)

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