Philadelphia 76ers vs Boston Celtics Prediction, 10/22/2025 Preview and Pick

Game: Philadelphia 76ers vs Boston Celtics

Date: Wednesday, October 22, 2025

Location: TD Garden in Boston, MA

TV: NBC Sports Boston

Odds/Point Spread: Philadelphia (+2.5)

The Boston Celtics (61-21 last season) will compete against the Philadelphia 76ers (24-58 last year) at TD Garden on Wednesday. Philadelphia opens this game as 2.5-point dogs. The over/under has been set at 226.5.

The 76ers played the Bulls and ended up losing by a score of 122-102 in their last contest. Philadelphia wrapped up the contest with a 38.3% FG percentage (36 of 94) and knocked down 12 out of their 44 shots from beyond the arc. At the charity stripe, the 76ers made 18 of 21 shots for a rate of 85.7%. With respect to getting rebounds, they earned 48 with 10 of them being offensive. They also doled out 20 assists in this game in addition to forcing the other team into 13 turnovers and getting 7 steals. Concerning defense, Philadelphia let their opponent shoot 45.6% from the field on 47 of 103 shooting. Chicago recorded 29 assists and had 10 steals in the matchup. In addition, Chicago collected 59 boards (15 offensive, 44 defensive) and got 6 blocks. Chicago finished shooting 75.0% from the free throw line by converting 15 of 20 attempts. They also made 13 out of their 40 tries from beyond the arc. When it comes to fouls, the 76ers ended up with 15 and the Bulls racked up 17 fouls.

Lonnie Walker IV is a player who was a major contributor for this contest. He walked away with 31 points on 11 of 23 shooting. He was on the court for 37 minutes and grabbed 6 boards. Walker finished the game at 47.8% from the floor and totaled 2 assists.

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Philadelphia enters this matchup after finishing with a record of 24-58 last year. They averaged 109.6 points per outing (26th in the league) on 45.4% from the field. The 76ers connected on 34.1% on 3-point shots (1,041 of 3,050) and 78.0% from the free throw line. As a basketball team, Philadelphia collected 39.8 rebounds per game and racked up 1,901 assists throughout last year, which had them ranked 29th in the NBA in terms of passing. They lost possession by turning the ball over 13.6 times per game and as a team committed 19.0 fouls every game.

When they were on defense, the 76ers forced their opponents into 16.0 turnovers every game and they drew 18.7 fouls. They relinquished 37.8% on three-point shots and they were 21st in the NBA in PPG allowed (115.8). The 76ers defensively gave up a field goal percentage of 48.8% (3,475 of 7,118) and they relinquished 45.5 rebounds per contest as a team. They were ranked 25th in the NBA in allowing assists to their opponents with 2,317 relinquished last season.

In their last game, the Celtics went home defeated by a final of 119-81 when they faced the Knicks. The Celtics were able to pull down 27 defensive boards and 9 offensive rebounds for a total of 36 in this matchup. They gave up possession of the ball 16 times, while earning 4 steals in the game. The Knicks had 23 personal fouls for the game which got the Celtics to the free throw line for a total of 10 attempts. They were able to convert 7 of those for a percentage of 70.0%. In regard to 3-point shots, Boston converted 12 of 40 tries (30.0%). When the final whistle blew, the Celtics went 31 for 86 from the floor which gave them a shooting percentage of 36.0%. The Celtics permitted the Knicks to convert 42 out of 91 tries from the field which left them shooting 46.2% for the contest. They finished 35.6% from distance by going 16 of 45 and ended up shooting 19 out of 21 at the free throw line (90.5%). When discussing attacking the glass, Boston allowed New York to get 55 in all (15 offensive).

Jaylen Brown was important for the Celtics in the matchup. Brown tallied 20 points in his 32 minutes on the court and had 6 dimes in this matchup. He converted 8 of 20 in this contest giving him a rate of 40.0%, and added 6 rebounds.

Boston had a record of 61-21 last year. The Celtics were responsible for committing 15.9 personal fouls every game and they connected on 79.9% from the charity stripe. They dished out assists 26.1 times per game (16th in the league) and they coughed up possession 11.9 times per game. Boston tallied 9,534 points over the course of last season (116.3 per contest) and they snagged 45.3 boards per game. When it comes to executing on offense, the Celtics shot 46.2% from the floor, which ranked them 19th in the NBA.

The Celtics defensively were ranked 2nd in the league in PPG given up with 107.2. They were able to force 12.8 TO's every game and allowed teams to shoot 45.0% from the field (2nd in the league). The Boston defense conceded 34.7% on shots from behind the 3-point line (1,055 of 3,041) and their opponents made 77.7% of their shots from the charity stripe. They gave up 24.0 dimes and 43.7 rebounds per game, which was ranked 3rd and 13th in those categories on the defensive end.

Who will win tonight's NBA game against the spread?

Tony Sink's Pick: Take Philadelphia (+2.5)

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