Cleveland Cavaliers vs Philadelphia 76ers Prediction, 10/22/2026 Preview and Pick

Game: Cleveland Cavaliers vs Philadelphia 76ers

Date: Thursday, October 22, 2026

Location: Xfinity Mobile Arena in Philadelphia, PA

TV: NBC Sports Philadelphia

Odds/Point Spread: Cleveland (+3.5)

The Cleveland Cavaliers (52-30 last season) are on their way to Xfinity Mobile Arena on Thursday where they will attempt to defeat the Philadelphia 76ers (45-37 last year). Philadelphia opens this contest as 3.5-point favorites. The over/under has been set at 235.5.

The Cavaliers faced off with the Knicks and took a loss by a final of 130-93 in their last contest. Regarding fouls, the Cavaliers ended up with 18 while the Knicks totaled 20 fouls. They made 19 of 43 tries from long range. New York ended up going 75.0% at the charity stripe by converting 15 of 20 shots. In addition, New York grabbed 60 rebounds (20 offensive, 40 defensive) and got 4 blocks. New York doled out 33 assists and had 15 steals for the contest. In terms of defending, Cleveland allowed their opponent to shoot 49.0% from the floor on 48 out of 98 shooting. They also doled out 21 assists in this contest in addition to forcing 15 turnovers and getting 9 steals. With regard to rebounding, they earned 33 with 6 of them being of the offensive variety. When they shot from the charity stripe, the Cavaliers knocked down 18 of their 22 shots for a rate of 81.8%. Cleveland ended having earned a 41.6% field goal percentage (32 out of 77) and converted 11 of their 40 shots from distance.

Donovan Mitchell is one player who played a role in this matchup. He scored 31 points on 9 of 18 shooting. He was on the hardwood for 32 minutes and also collected 4 rebounds. Mitchell finished 50.0% from the floor and earned 1 assist.

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Cleveland comes into this game after finishing with a record of 52-30 last season. They lost possession via turnover 14.0 times per contest and as a squad committed 19.6 personal fouls every game. As a team, Cleveland collected 44.4 rebounds per game and had 2,321 assists last season, which ranked 8th in basketball in terms of passing the rock. The Cavaliers connected on 36.0% on three-point shots (1,173 of 3,261) and 77.6% from the charity stripe. They had an average of 119.5 points per game (4th in basketball) while connecting on 48.2% from the floor.

When they were on defense, the Cavaliers forced 15.0 turnovers every game and they drew 20.5 personal fouls. They gave up 37.2% on 3-point attempts and they were 15th in the NBA in PPG from their opponents (115.4). The Cavaliers defense allowed a field goal percentage of 46.4% (3,387 of 7,303) and they relinquished 43.2 boards per game as a basketball team. They were ranked 16th in the league in giving up assists with 2,208 surrendered last year.

The last time they took the hardwood, the 76ers took home the win by a final score of 106-100 when they played the Knicks. In regard to cleaning up the glass, Philadelphia permitted New York to get 53 in all (14 offensive). They went 33.3% from three-point range by connecting on 11 out of 33 and ended up going 19 of 27 at the free throw line (70.4%). The 76ers allowed the Knicks to knock down 35 of their 94 tries from the floor which gave them a shooting percentage of 37.2% in the matchup. When the game finished, the 76ers shot 37 out of 89 from the floor which had them shooting 41.6%. In reference to three-point shots, Philadelphia buried 11 of 40 tries (27.5%). They were able to bury 21 of the free throw attempts for a percentage of 77.8%. The Knicks committed 22 fouls in this game which took the 76ers to the charity stripe for a total of 27 tries. They turned the ball over 12 times, while getting 8 steals in this matchup. The 76ers were able to collect 39 defensive rebounds and 6 offensive rebounds totaling 45 for the contest.

Tyrese Maxey ended up being a major contributor for the 76ers in the matchup. Maxey had 28 points in his 40 minutes on the court and had 5 dimes for this game. He buried 9 of 19 for the matchup giving him a field goal percentage of 47.4%, and earned 4 rebounds.

Philadelphia had a win-loss mark of 45-37 last season. The 76ers committed 20.3 fouls per contest and they went 80.9% from the charity stripe. They earned an assist 24.6 times per game (29th in the league) and they turned it over 13.6 times per game. Philadelphia earned 9,502 points last season (115.9 per contest) and they averaged 43.6 boards per game. When it comes to offensive execution, the 76ers connected on 46.2% from the field, which ranked 23rd in the NBA.

The Philadelphia defense gave up 35.3% on 3-pointers (1,097 of 3,108) and opponents connected on 78.5% of their free throw shots. They allowed 27.6 assists and 45.3 boards on a nightly basis, which was ranked 22nd and 22nd in the league. The 76ers defensively were ranked 19th in the NBA in PPG allowed with 116.1. They were able to force 15.4 TO's per game and allowed teams to shoot 46.7% from the floor (12th in the NBA).

Who will win tonight's NBA game against the spread?

Tony Sink's Pick: Take Cleveland (+3.5)

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