Detroit Red Wings vs Buffalo Sabres Prediction, 10/22/2025 NHL Picks, Best Bets & Odds

Game: Detroit Red Wings vs Buffalo Sabres

Date: Wednesday, October 22, 2025

Location: KeyBank Center in Buffalo, NY

TV: TNT/HBO Max

Odds/Point Spread: Red Wings (-152) Sabres (+126)

The Detroit Red Wings (5-1-0) are hitting the road to KeyBank Center on Wednesday where they will play the Buffalo Sabres (2-4-0). The moneyline on this contest has Detroit at -152 and Buffalo is at +126. The over/under comes in at 6.

The Detroit Red Wings were on the right side of the scoreboard with a 4-2 victory against the Oilers in their previous outing. Detroit accounted for 2 mins in the box for this matchup. The Red Wings had a good offensive outing and it showed in the victory. Additionally, they had 1 power play opportunity but weren't able to score. For the game, they converted 4 out of the 24 shots they tried.

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When at even strength, the Red Wings have allowed 13 goals while notching 16 of their own. Detroit Red Wings opponents have earned 13 power play opportunities (31st in hockey) and have racked up 1 goal in those chances. Pertaining to their goal scoring prowess, the Detroit Red Wings have tallied 20 goals (9th in the league) for the season and have given up 14. Detroit has taken 162 shots and holds a shot percentage of 12.4%. For the year, the have a total of 10 points and their points percentage is .833. The Red Wings have seen 151 shots tried against them and are the owners of a save percentage of .907. Detroit is sitting with 18 power play chances and they have tallied 4 goals out of those advantages, earning them a rate of 22.22%.

Protecting the goal for this matchup will be John Gibson. Gibson has participated in 509 matchups over the course of his hockey career. He has compiled an overall record of 206-218-63 and was named the starter in 497 games. Opponents have notched 1,395 goals against Gibson in his pro hockey career and his goals against average per game is 2.81. Gibson has seen 15,483 shot attempts against him and has accrued 14,088 saves. His save percentage is at .910 for his 26,825 mins played. During his career on the ice, Gibson is sitting with 270 quality starts and his rate for quality starts is .543.

Their last time out, Buffalo went up against the Canadiens in an outing where the Sabres took a loss by a final score of 4-2. They had 1 power play opportunity in this contest but weren't able to notch a goal. The Sabres recorded 2 goals of the 32 shots on goal they tried.

The Sabres have scored 10 goals at even strength and 5 goals (9th in pro hockey) while on the power play. Buffalo has attempted 177 shots (13th in hockey) and has earned a shot percentage of 8.47%, while allowing the other team 201 shots. On the campaign, the Buffalo Sabres have accounted for 15 goals, 4 points, and a points percentage of .333. They have permitted 18 goals to be scored by of a combination of 17 goals at even strength and 1 goal while they were shorthanded. They have earned 19 chances on the power play and they have a power play percentage of 26.32%. They have accumulated a penalty kill percentage of 95.83% on their opponents 24 power play opportunities, and their save percentage comes in at 91.0%.

On the other side of the ice you are likely to see Alex Lyon defending the net. Teams are averaging 3.00 goals per game and he has allowed 318 goals overall. Lyon's quality start percentage comes out to 52.8% and he has qualified for 56 quality starting assignments in his professional career. He has started in 106 games and his ice time sits at 6,004 mins. Lyon is the owner of a career record of 53-42-11 and has participated in 119 contests. He has gathered 2,967 saves out of 3,285 shots attempted, which gives him a percentage of .903.

Who will win tonight's NHL game against the spread or moneyline?

Guy's Pick: Take Buffalo (+126)

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