Boston Bruins vs Buffalo Sabres Prediction, 4/21/2026 NHL Picks, Best Bets & Odds

Game: Boston Bruins vs Buffalo Sabres

Date: Tuesday, April 21, 2026

Location: KeyBank Center in Buffalo, NY

TV: ESPN

Odds/Point Spread: Bruins (+142) Sabres (-170)

The Boston Bruins (45-27-10) are headed to KeyBank Center on Tuesday where they will take on the Buffalo Sabres (50-23-9) in Game 2 of their series. Buffalo leads 1-0. The moneyline on this game has the Bruins at +142 while the Sabres are priced at -170. The total has been set at 6.5.

The Boston Bruins were on the losing side of the ice with a 4-3 defeat against the Sabres in Game 1. The Bruins had an average offensive performance in the loss. In the game, they converted 3 of the 20 shots they launched. They also had 3 power play tries and were able to net 1 goal. Boston accounted for 12 penalty minutes in this contest.

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While playing at even strength, the Bruins have conceded 183 goals while earning 213 of their own. Boston Bruins opponents have tallied 278 power play opportunities (1st in the NHL) and have a total of 64 goals in those chances. With respect to their scoring, the Boston Bruins have tallied 268 goals (11th in the league) on the season and have conceded 247. Boston has tried 2,216 shots and holds a shooting percentage of 12.1%. For the year, the have a total of 100 points and their points % is .610. The Bruins thus far have had 2,435 shots taken against them and hold a save percentage of .899. Boston comes into tonight with 235 power play chances and they have scored 55 goals during those advantages, garnering them a rate of 23.40%.

The player protecting the goal in this game is Jeremy Swayman. The opposition has notched 617 goals against Swayman in his pro hockey career and his goals against average is 2.60. Swayman has participated in 245 matchups during his hockey career. His save percentage currently is .910 during his 10,205 mins guarding the cage. He has an overall record of 132-80-26 and he has started in 237 games. For his career, Swayman has accumulated 148 quality starts and his quality starts percentage is .624. Swayman has had 6,825 shots taken against him and has garnered 6,208 saves.

In Game 1, the Sabres converted 4 goals of the 38 shots on goal they attempted. Buffalo had 4 power play opportunities in this contest but weren't able to notch a goal.

So far this year, the Buffalo Sabres have accounted for 283 goals, 109 points, as well as a points percentage of .665. They have allowed 240 goals to be scored by of a combination of 198 goals at even strength and 42 goals while they were shorthanded. The Sabres have tallied 235 goals at even strength and 48 goals (18th in hockey) while on the power play. They have a tally of 246 chances on the power play and they have accumulated a power play rate of 19.51%. Buffalo has put up 2,307 shots (13th in professional hockey) and has accumulated a shot percentage of 12.27%, while allowing their opponents 2,381 shots. They have a penalty kill percentage of 81.90% on their oppositions 232 chances on the power play, and their save percentage sits at 89.9%.

On the other side of the ice you are going to see Ukko-Pekka Luukkonen in goal. He is sitting with 4,830 saves out of 5,368 shots taken, which gives him a save percentage of .900. Luukkonen has earned a career mark of 93-74-18 and has participated in 190 games. He has started in 185 contests and has played 8,299 mins. Luukkonen's quality start percentage is 55.1% and he has qualified for 102 quality starting assignments in his hockey career. Opponents are averaging 2.91 goals/game and he has allowed 538 goals altogether.

Who will win tonight's NHL game against the spread or moneyline?

Guy's Pick: Take Buffalo (-170)

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