Appalachian State Mountaineers vs Charlotte 49ers Prediction, 8/29/2025 College Football Picks, Best Bets & Odds

Game: Appalachian State Mountaineers vs Charlotte 49ers

Date: Friday, August 29, 2025

Location: Bank of America Stadium in Charlotte, NC

TV: ESPN/ESPN+

Odds/Point Spread: 49ers (+6.5)

Total/Over-Under: 50.5

The Appalachian State Mountaineers (5-6 last season) are headed to Bank of America Stadium on Friday, August 29, 2025 where they will play the Charlotte 49ers (5-7 last year). Appalachian State opens this game as 6.5-point favorites. The over/under is 50.5.

The Appalachian State Mountaineers finished the season with a 5-6 record. In their last contest, the Mountaineers took the field against the Georgia Southern Eagles and ended up losing by a score of 29-20. The Appalachian State Mountaineers ended up rushing 39 different times and tallied 175 yards, which came out to an average of 4.5 yards per attempt. For the game, they ran 74 plays which converted into 465 yards. Appalachian State allowed 16 pass completions on 19 attempts for a total of 166 yds, and a completion rate of 84.2%. In the running game, the Mountaineers conceded 191 yds on 41 attempts, which is an average of 4.7 yards per run allowed.

The Mountaineers earned 4,695 total yards last year. Appalachian State compiled 23 touchdowns via the pass and 13 touchdowns on the ground. They gave the ball to the opposition 22 times. Appalachian State had 262 1st downs as a team, and they were called for 66 penalties for 626 yards. As a unit they held an average of 153.8 yds via the ground game, giving them a rank of 77th in the nation. Regarding scoring, the Appalachian State Mountaineers had an average of 26.6 PPG.

When it comes to yards through the air, the Mountaineers allowed 2,363 yds which had them ranked 21st in the nation. In their 11 games played last year, they surrendered 214.8 yards per game through the air and relinquishing a completion percentage of 68.8%. They allowed 412.5 yards/game which ranked them 104th in the nation. They conceded 20 passing touchdowns in addition to 24 rushing touchdowns. They allowed teams to run for an average of 5.3 yards per rushing attempt and 197.6 yards on the ground per game last season. During the campaign, they conceded 2,174 rushing yards through 11 games. The Mountaineers were ranked 115th in the country regarding team defense, conceding 32.9 PPG.

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The 49ers ended the year holding a 5-7 mark. The last time they took the field, the 49ers took home the win by a final score of 29-27 against the UAB Blazers. Charlotte gave up 35 rushing attempts for 128 yds (3.7 yards per carry). The 49ers pass defense allowed a completion percentage of 66.7%, surrendering 309 yards on 28 for 42 passing. The 49ers finished the contest with 355 yds while running 61 plays (5.8 yds per play). Charlotte ran the ball for 4.0 yds per carry, finishing with 140 yards on 35 attempts.

The Charlotte 49ers maintained an average of 341.2 yards per contest, which was good for 105th in the nation. The Charlotte offense compiled 784 yards of penalties on 94 infractions, which ranked 25th in the nation in terms of making mistakes. They averaged 117.1 yards per game on the ground and ran for 1,405 yards for last year. They gave away 14 picks while surrendering 7 fumbles and they earned 206 first downs. Regarding the points being put on the board, the 49ers ranked 100th in D-1 by scoring 23.7 points per game. Last year, the 49ers earned 2,689 passing yards in addition to averaging 224.1 passing yards per game, giving them a rank of 73rd in the nation.

The 49ers allowed 35.1 points per contest, ranking them 123rd in college football. Charlotte conceded a total of 2,524 rushing yards (210.3 yards per game) and 29 touchdowns via the rush last year. In total, they gave up 421 total points. They yielded 18 touchdowns from the passing game and 222.8 yards/game, which had them in 74th in the nation. The 49ers defense took part in 826 plays, which was good for 54th in the country. Their defense totaled 2 fumbles recovered and 10 picks over the course of last season.

Who will win tonight's Mountaineers/49ers college football game against the spread?

Tony's Pick: Take the 49ers +6.5

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