Arizona Wildcats vs Colorado Buffaloes Prediction, 11/1/2025 College Football Picks, Best Bets & Odds

Game: Arizona Wildcats vs Colorado Buffaloes

Date: Saturday, November 1, 2025

Location: Folsom Field in Boulder, CO

TV: FS1

Odds/Point Spread: Buffaloes (+5.0)

Total/Over-Under: 52.5

Folsom Field is the site where the Colorado Buffaloes (3-4) will take on the Arizona Wildcats (4-3) on Saturday, November 1, 2025. Colorado opens as 5.0-point underdogs. The over/under comes in at 52.5.

The Arizona Wildcats head into this game 4-3 this season. The last time they stepped onto the field, the Wildcats took on the Houston Cougars and took a loss by a final of 31-28. Overall, they tallied 57 plays which gave them a total of 381 yds. The Arizona Wildcats ran the ball 31 times and recorded 112 yds, which had them averaging 3.6 yds per carry. Against the run, the Wildcats conceded 232 yds on 45 attempts, which averages out to 5.2 yards per run allowed. Arizona conceded 15 pass completions on 23 tries for a total of 164 yds, and a completion rate of 65.2%.

Regarding scoring, the Arizona Wildcats are averaging 31.6 points per outing. As a team they're maintaining an average of 142.1 yards in the run game which ranks them 85th in college football. The Wildcats have earned 2,914 total yards for the year. In terms of scoring touchdowns, Arizona has amassed 17 passing touchdowns and 9 rushing touchdowns. Arizona has tallied 160 1st downs as an offense, and they have been flagged for 41 penalties for 358 yards. They have turned the ball over 8 times.

When it comes to passing yards, the Wildcats have given up 1,072 yds which ranks them 6th in D-1. They are giving up 153.1 yards per contest via the pass and giving up a completion percentage of 51.6%. For the season, they have surrendered 292.9 yards per outing ranking them 17th in college football. They have granted 4 touchdowns by air and 11 touchdowns pounding the rock. They are giving up an average of 3.8 yards per rushing attempt and 139.7 yards on the ground per game on the campaign. In total, they have allowed 978 rushing yards through 7 games. The Wildcats rank 36th in the nation when it comes to team defense, conceding 20.3 PPG.

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The Buffaloes come into this game with a record of 3-4 this season. In their last game, the Buffaloes walked away with a loss by a score of 53-7 when they played the Utah Utes. Colorado allowed 51 rushing attempts for 422 yds (8.3 yards per carry). The Buffaloes secondary gave up a completion rate of 44.0%, surrendering 165 yards on 11 for 25 through the air. The Buffaloes ended up finishing with 140 yards and they ran 68 plays (2.1 yards per play). Colorado rushed the ball for 1.0 yds per attempt, totaling 38 yds on 38 attempts.

The Colorado Buffaloes average 333.6 yards per contest, which has them ranked 109th in college football. The Colorado offense has compiled 351 yards of penalties on 40 infractions, which is 108th in D-1 in terms of hurting your team. They maintain an average of 130.1 rushing yards per game and have toted the ball for 1,041 yards for the season. They have given away 7 interceptions while surrendering 2 fumbles and they have been able to obtain 143 first downs. In terms of this team's ability to score points, the Buffaloes currently rank 102nd in D-1 scoring 22.6 points per game. During this campaign thus far, the Buffaloes have thrown for a total of 1,628 yards via the pass in addition to an average of 203.5 passing yards per outing, giving them a rank of 97th in D-1.

The Buffaloes are relinquishing 27.4 PPG, ranking them 88th in D-1. Colorado has yielded a total of 1,738 yards via the ground game (217.3 yards per game) as well as 14 touchdowns on the ground for the year. They have given up 11 touchdowns via the pass as well as 210.4 yards per game, which puts them in 54th in the country. The Buffaloes defense has been on the field for 557 plays, which ranks 113th in Division 1. They have earned 3 fumbles and 3 picks on the year. In total, they have given up 219 points.

Who will win tonight's Wildcats/Buffaloes college football game against the spread?

Tony's Pick: Take the Wildcats -5.0

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