Boston College Eagles vs Louisville Cardinals Prediction, 10/25/2025 College Football Picks, Best Bets & Odds

Game: Boston College Eagles vs Louisville Cardinals

Date: Saturday, October 25, 2025

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ACC Network

Odds/Point Spread: Cardinals (-25.0)

Total/Over-Under: 55.5

The Boston College Eagles (1-6) are traveling to L&N Federal Credit Union Stadium on Saturday, October 25, 2025 where they will try to defeat the Louisville Cardinals (5-1). Boston College opens this matchup as 25.0-point dogs. The total has been set at 55.5.

The Boston College Eagles head into this matchup 1-6 this season. In their last contest, the Eagles took on the Connecticut Huskies and went home with a loss by a final score of 38-23. The Boston College Eagles ended up running the ball 49 times and amassed 191 yds, which had them averaging 3.9 yards per carry. Once the final whistle blew, they tallied 77 plays which gave them 395 yards. Boston College surrendered 23 pass completions on 31 attempts for 362 yards, and a completion rate of 74.2%. In the running game, the Eagles gave up 93 yards on 27 tries, which averages out to 3.4 yards per run surrendered.

In terms of putting points on the board, the Boston College Eagles are averaging 27.1 points per contest. As a unit they average 100.1 yards on the ground ranking them 128th in the nation. The Eagles have racked up 2,608 total yards over the course of this year. When it comes to distribution of touchdowns, Boston College has compiled 13 passing touchdowns and 9 rushing touchdowns. Boston College has amassed 140 first downs as a team, and they have committed 45 penalties for 380 yards. They have surrendered the football 11 different times.

The Eagles sit in 126th in Division 1 when it comes to the opposition scoring, giving up 33.9 PPG. The opposition is running for an average of 4.0 yards per run and 141.0 rushing yards per game so far this year. For the season, they have given up 987 rushing yards through 7 outings. When it comes to passing yards, the Eagles have allowed 1,794 yards which puts them in 117th in Division 1. They have yielded 256.3 yards per game through the air and allowed a completion percentage of 65.2%. During the season, they have relinquished 397.3 yards per game which ranks them 103rd in Division 1. They have yielded 16 touchdowns via the pass as well as 12 touchdowns via the ground game.

Get all of our College Football Picks

The Cardinals head into this matchup 5-1 this season. When they last stepped on the gridiron, the Cardinals went home victorious with a score of 24-21 when they faced the Miami Hurricanes. Louisville allowed 24 running attempts for 63 yards (2.6 yds per rush). The Cardinals pass defense gave up a completion percentage of 71.4%, relinquishing 271 yards on 25 out of 35 through the air. The Cardinals finished with 367 yds while running 68 plays (5.4 yds per play). Louisville ended up running for 3.8 yds per carry, finishing the contest with 119 yards on 31 carries.

The Louisville Cardinals are averaging 397.8 yards per outing, which is good for 64th in the nation. The Louisville offense has 426 penalty yards on 43 infractions, which ranks 63rd in D-1 in terms of helping out the opposition. They maintain an average of 115.7 yards via the ground game and have run for 694 yards for this season. They have thrown 5 interceptions while surrendering 4 fumbles and they have earned 131 1st downs. When it comes to how much they score, the Cardinals sit 37th in the country averaging 34.0 points per game. For the season so far, the Cardinals have earned 1,693 passing yards together with an average of 282.2 throwing yards per contest, which ranks 22nd in D-1.

Louisville has allowed a total of 621 yards rushing (103.5 yards/game) in addition to 6 touchdowns via the rush on the season. They have yielded 5 touchdowns from the passing game and 170.5 yards/contest, which puts them in 20th in college football. In total, they have conceded 126 total points. They have tallied 3 fumbles and 10 picks for the season. The Cardinals defense has taken part in 358 plays, which ranks them 1st in college football. The Cardinals are giving up 21.0 points per contest, which has them ranked 44th in the nation.

Who will win tonight's Eagles/Cardinals college football game against the spread?

Josh's Pick: Take the Eagles +25.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.