Boston College Eagles vs Pittsburgh Panthers Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Boston College Eagles vs Pittsburgh Panthers

Date: Saturday, October 4, 2025

Location: Acrisure Stadium in Pittsburgh, PA

TV: ACC Network

Odds/Point Spread: Panthers (-6.5)

Total/Over-Under: 57

Acrisure Stadium is the location where the Pittsburgh Panthers (2-2) will play the Boston College Eagles (1-3) on Saturday, October 4, 2025. Pittsburgh opens this game as 6.5-point favorites. The total is 57.

The Boston College Eagles step onto the field holding a record of 1-3 for this year. In their last game, the Eagles played against the California Golden Bears and took a loss by a score of 28-24. The Boston College Eagles rushed the ball a total of 21 different times and recorded 178 yds, which had them averaging 8.5 yds per carry. In all, they had 58 plays which converted into 375 yards. Boston College conceded 22 pass completions on 34 tries for 254 yards, and a completion rate of 64.7%. Against the rush, the Eagles conceded 118 yds on 37 attempts, which is an average of 3.2 yards per rush surrendered.

The Eagles have earned 1,776 total yards this year. When it comes to distribution of touchdowns, Boston College has compiled 10 touchdowns via the pass and 8 touchdowns via the ground. They have turned the ball over 6 different times. Boston College has accounted for 90 first downs as an offense, and they have been called for 29 infractions for 213 yards. Offensively they're holding an average of 99.5 yards rushing ranking them 127th in the nation. Concerning putting points on the board, the Boston College Eagles are averaging 37.5 points per game.

Regarding passing yardage, the Eagles are giving up 823 yds which has them sitting in 41st in college football. They are giving up 205.8 yards per outing via the pass and allowed a completion percentage of 59.7%. During this campaign, they have relinquished 329.8 yards/contest ranking them 51st in college football. They have yielded 7 touchdowns via the pass and 5 touchdowns pounding the rock. They are allowing teams to run for an average of 3.6 yards per rush and 124.0 yards on the ground per game for the year. Overall, they have given up 496 yards via the running game in 4 games. The Eagles are sitting in 98th in the country concerning their opponents scoring, allowing 27.5 points per game.

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The Panthers head into this matchup 2-2 for this season. For their last game, the Panthers took a loss by a final score of 34-27 when they faced the Louisville Cardinals. Pittsburgh rushed the football for 3.5 yds per attempt, totaling 80 yards on 23 attempts. The Panthers finished the game with a total of 339 yds while running 55 plays (6.2 yards per play). The Panthers passing defense allowed a completion percentage of 64.7%, relinquishing 339 yards on 33 out of 51 passing. Pittsburgh conceded 34 rushing attempts for 53 yds (1.6 yds per rush).

In terms of the points being put on the board, the Panthers currently rank 17th in Division 1 holding an average of 39.3 points per game. The Pittsburgh Panthers average 403.0 yards per contest, which has them sitting 64th in the nation. The Pittsburgh offense has compiled 254 penalty yds on 29 violations, which is 53rd in D-1 in terms of helping out the other team. They have tossed 6 interceptions while losing 2 fumbles and they have obtained 72 first downs. During this campaign thus far, the Panthers have thrown for a total of 1,204 passing yards as well as holding an average of 301.0 passing yards per outing, putting them at 18th in the country. They are averaging 102.0 rushing yards per game and have run for 408 yards overall.

Pittsburgh has allowed a total of 296 yards rushing (74.0 yards per outing) as well as 5 touchdowns on the ground so far this year. They have allowed 6 touchdowns through the air in addition to 236.8 yards/game, which has them sitting 91st in the nation. Overall, they have surrendered 91 points in total. They have compiled 1 fumble and 3 picks over the course of the season. The Panthers defense has been on the field for 301 plays, which ranks 78th in the nation. The Panthers are relinquishing 22.8 PPG, which has them 60th in the country.

Who will win tonight's Eagles/Panthers college football game against the spread?

Guy's Pick: Take the Eagles +6.5

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