Clemson Tigers vs Louisville Cardinals Prediction, 11/14/2025 College Football Picks, Best Bets & Odds

Game: Clemson Tigers vs Louisville Cardinals

Date: Friday, November 14, 2025

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ESPN

Odds/Point Spread: Cardinals (-3.5)

Total/Over-Under: 51.5

L&N Federal Credit Union Stadium is the location where the Louisville Cardinals (7-1) will play the Clemson Tigers (3-5) on Friday, November 14, 2025. Clemson is 3.5-point underdogs from oddsmakers. The total is 51.5.

The Clemson Tigers head into this matchup 3-5 for this season. The last time they stepped onto the field, the Tigers went up against the Florida State Seminoles and notched a win by a score of 24-10. Against the run, the Tigers gave up 110 yds on 26 tries, which averages out to 4.2 yards per run surrendered. Clemson surrendered 23 completions on 43 tries for 250 yards, and a completion percentage of 53.5%. On the day, they ran 63 plays which gave them 319 yds. The Clemson Tigers ran the football 36 times and had 98 yards, which had them averaging 2.7 yards per attempt.

In terms of getting in the endzone, the Clemson Tigers are averaging 28.4 points per contest. As a team they're holding an average of 123.8 yards in the run game giving them a rank of 109th in Division 1. The Tigers currently have 3,365 yards in total over the course of this season. In terms of getting the ball in the endzone, Clemson has earned 17 passing touchdowns and 12 touchdowns via the ground. Clemson has recorded 175 first downs as an offense, and they have committed 39 penalties for 396 yards. They have surrendered the football 13 different times.

The Tigers are ranked 66th in Division 1 when it comes to team defense, allowing 24.0 points per game. They are allowing teams to run for an average of 3.5 yards per run and 105.8 rushing yards per contest this year. For the year, they have allowed 846 yards via the ground game in 8 outings. Regarding yards through the air, the Tigers have given up 1,956 yards which has them ranked 81st in college football. They are allowing 244.5 yards per game via the pass and allowed a completion percentage of 61.5%. During the season, they have given up 350.3 yards/outing which ranks them 53rd in the country. They have conceded 11 touchdowns by air and 9 touchdowns on the ground.

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The Cardinals come into this game with a record of 7-1 for this season. When they last stepped on the gridiron, the Cardinals took a defeat with a final score of 29-26 against the California Golden Bears. Louisville relinquished 25 running attempts for 77 yds (3.1 yds per rush). The Cardinals pass defense gave up a completion percentage of 63.3%, surrendering 350 yards on 31 for 49 through the air. The Cardinals finished the contest with a total of 351 yds on 69 plays (5.1 yards per play). Louisville rushed for 4.9 yards per carry, finishing with 148 yards on 30 attempts.

Concerning their ability to score points, the Cardinals are sitting 36th in the country with 33.8 points per game. The Louisville Cardinals are averaging 407.8 yards per outing, which has them ranked 59th in Division 1. The Louisville offense has 523 penalty yds on 55 infractions, ranking them 58th in Division 1 in terms of giving up free yards. They have tossed 7 interceptions while conceding 6 fumbles and they have been able to tally 165 first downs. Over the course of the season to this point, the Cardinals have earned 2,016 yards through the air as well as an average of 252.0 passing yards per game, which ranks 46th in the nation. They hold an average of 155.8 yards via the ground game and have toted the ball for 1,246 yards for the season.

Louisville has allowed a total of 901 yards via the ground game (112.6 yards per game) as well as 7 touchdowns via the rush for the year. They have allowed 9 touchdowns through the air as well as 167.9 yards per outing, which has them sitting 14th in the nation. In total, they have given up 166 points. Their defense has compiled 4 fumbles and 12 picks over the course of the season. The Cardinals defense has taken part in 504 plays, which ranks 12th in Division 1. The Cardinals are relinquishing 20.8 PPG, which has them ranked 33rd in D-1.

Who will win tonight's Tigers/Cardinals college football game against the spread?

Josh's Pick: Take the Cardinals -3.5

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