Clemson Tigers vs North Carolina Tar Heels Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Clemson Tigers vs North Carolina Tar Heels

Date: Saturday, October 4, 2025

Location: Kenan Stadium in Chapel Hill, NC

TV: ESPN

Odds/Point Spread: Tar Heels (+14.0)

Total/Over-Under: 45.5

The Clemson Tigers (1-3) are headed to Kenan Stadium on Saturday, October 4, 2025 where they will try to beat the North Carolina Tar Heels (2-2). Clemson opens this contest as 14.0-point favorites. The total comes in at 45.5.

The Clemson Tigers head into this game 1-3 for this year. The last time they took the field, the Tigers played the Syracuse Orange and walked away from this one with a loss by a score of 34-21. Once the final whistle blew, they tallied 83 plays for 503 yds. The Clemson Tigers ended up rushing 22 different times and amassed 140 yards, which earned them an average of 6.4 yds per carry. Against the run, the Tigers conceded 155 yards on 38 tries, which is 4.1 yds per run allowed. Clemson gave up 21 pass completions on 39 attempts for 278 yards, and a completion rate of 53.8%.

The Tigers have earned 1,461 total yards for this campaign. When it comes to getting in the endzone, Clemson has totaled 6 passing touchdowns and 4 touchdowns via the ground. They have turned the football over 7 times. Clemson has accounted for 76 1st downs as an offense, and they have committed 19 penalties for 187 yds. Offensively they average 116.3 yards in the run game ranking them 112th in D-1. Regarding putting points on the board, the Clemson Tigers have an average of 19.8 points per contest.

The Tigers rank 63rd in the country regarding team defense, allowing 22.8 PPG. They are allowing teams to run for an average of 3.4 yards per tote and 121.8 rushing yards per game for the season. During this campaign, they have given up 487 yards via the running game in 4 outings. Regarding yards through the air, the Tigers are giving up 961 yards which puts them in 69th in Division 1. They have surrendered 240.3 yards per outing through the air and allowed a completion percentage of 65.0%. For the season, they are granting 362.0 yards per game ranking them 73rd in the country. They have yielded 5 touchdowns through the air as well as 4 touchdowns on the ground.

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The Tar Heels come into this game with a record of 2-2 for this year. The last time they took the gridiron, the Tar Heels went home defeated by a final of 34-9 when they faced the UCF Knights. The Tar Heels ended up finishing with 217 yards and they ran 58 plays (3.7 yards per play). North Carolina ended up running for 2.5 yards per tote, finishing the game with 63 yds on 25 attempts. North Carolina relinquished 34 rush attempts for 143 yds (4.2 yards per rush). The Tar Heels secondary allowed a completion rate of 78.1%, surrendering 223 yds on 25 out of 32 through the air.

When looking at the points being put on the board, the Tar Heels are ranking 106th in college football by scoring 21.0 points per contest. The North Carolina Tar Heels have an average of 263.5 yards per outing, ranking them 134th in D-1. The North Carolina offense has totaled 180 yards of penalties on 17 infractions, which is 125th in college football in terms of helping out the opposition. They have thrown 4 picks while letting opponents recover 2 fumbles and they have been able to obtain 55 1st downs. During the season to this point, the Tar Heels have compiled 600 passing yards as well as an average of 150.0 throwing yards per contest, putting them at 124th in the nation. They have an average of 113.5 yards per game on the ground and have rushed for 454 yards for the season.

North Carolina has conceded a total of 546 yards on the ground (136.5 yards per game) and 5 touchdowns via the rush on the season. They have conceded 3 touchdowns via the pass and 208.0 yards/outing, which puts them in 64th in the country. Over the course of the season, they have relinquished 91 total points. They have earned 2 fumbles and 4 interceptions this year. The Tar Heels defense has been on the field for 272 plays, which is 47th in the country. The Tar Heels are relinquishing 22.8 PPG, which puts them 61st in the country.

Who will win tonight's Tigers/Tar Heels college football game against the spread?

Josh's Pick: Take the Tigers -14.0

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