Duke Blue Devils vs Syracuse Orange Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: Duke Blue Devils vs Syracuse Orange

Date: Saturday, September 27, 2025

Location: JMA Wireless Dome in Syracuse, NY

TV: ACC Network

Odds/Point Spread: Orange (+5.0)

Total/Over-Under: 60.5

JMA Wireless Dome is the location where the Syracuse Orange (3-1) will attempt to beat the Duke Blue Devils (2-2) on Saturday, September 27, 2025. Duke opens this game as 5.0-point favorites from Vegas oddsmakers. The over/under comes in at 60.5.

The Duke Blue Devils head into this matchup 2-2 for this season. In their last matchup, the Blue Devils faced the NC State Wolfpack and took home the win by a score of 45-33. When the final whistle blew, they tallied 63 plays which totaled 418 yds. The Duke Blue Devils ran the ball a total of 35 different times and tallied 149 yds, which came out to an average of 4.3 yards per attempt. On the ground, the Blue Devils conceded 171 yds on 35 attempts, which averages out to 4.9 yards per rush surrendered. Duke gave up 29 completions on 39 attempts for 364 yds, and a completion percentage of 74.4%.

The Blue Devils have racked up 1,856 yards in total this season. In terms of getting the ball in the endzone, Duke has amassed 11 touchdowns through the air and 5 touchdowns on the ground. They have turned the football over 7 times. Duke has compiled 93 1st downs as an offense, and they have been called for 26 penalties for 272 yards. As a unit they're maintaining an average of 132.3 yards in the run game ranking this team at 99th in the country. When it comes to getting in the endzone, the Duke Blue Devils are averaging 34.0 points per outing.

Concerning passing yards, the Blue Devils are allowing 1,042 yards which ranks them 116th in Division 1. They have given up 260.5 yards per game through the air in addition to allowing a completion percentage of 70.0%. Overall, they have yielded 413.8 yards per game putting them at 113th in college football. They have granted 5 touchdowns via the pass in addition to 12 touchdowns on the ground. They are giving up 3.9 yards per rush and 153.3 rushing yards per contest for the year. During the season, they have given up 613 rushing yards through 4 games. The Blue Devils are ranked 117th in college football in terms of their opponents scoring, conceding 32.3 points per game.

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The Orange head into this matchup 3-1 this season. When they last stepped on the gridiron, the Orange went home victorious with a score of 34-21 against the Clemson Tigers. Syracuse ran the ball for 4.1 yards per tote, finishing the game with 155 yards on 38 attempts. The Orange finished the game with 433 yds and they ran 77 plays (5.6 yds per play). The Orange pass defense allowed a completion rate of 60.7%, relinquishing 363 yards on 37 for 61 through the air. Syracuse gave up 22 running attempts for 140 yards (6.4 yards per carry).

In relation to their scoring prowess, the Orange are ranking 33rd in Division 1 holding an average of 38.3 PPG. The Syracuse Orange hold an average of 472.8 yards/contest, which is good for 23rd in Division 1. The Syracuse offense has totaled 175 yds of penalties on 21 violations, ranking them 78th in the country in terms of helping out the other team. They have thrown 3 interceptions while letting opponents recover 3 fumbles and they have recorded 104 first downs. For the year so far, the Orange currently sit at 1,415 passing yards as well as holding an average of 353.8 passing yards per game, which has them sitting 4th in Division 1. They hold an average of 119.0 yards via the ground game and have rushed for 476 yards in total.

The Orange are giving up 27.5 points per game, ranking them 99th in the nation. Syracuse has allowed a total of 635 rushing yards (158.8 yards per game) and 4 touchdowns by way of the ground game for the campaign. They have surrendered 9 touchdowns via the pass in addition to 296.3 yards/outing, which has them ranked 134th in Division 1. The Orange defense has been on the field for 312 plays, which ranks them 135th in Division 1. They have compiled 3 fumbles recovered and 3 interceptions so far this season. This year, they have relinquished 110 points.

Who will win tonight's Blue Devils/Orange college football game against the spread?

Tony's Pick: Take the Blue Devils -5.0

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