Eastern Michigan Eagles vs Buffalo Bulls Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Eastern Michigan Eagles vs Buffalo Bulls

Date: Saturday, October 4, 2025

Location: UB Stadium in Buffalo, NY

TV: ESPN+

Odds/Point Spread: Bulls (-10.0)

Total/Over-Under: 49.5

The Buffalo Bulls (2-3) are welcoming the Eastern Michigan Eagles (1-4) at UB Stadium on Saturday, October 4, 2025. Buffalo opens as 10.0-point favorites. The total is 49.5.

The Eastern Michigan Eagles head into this game 1-4 for this year. The last time they stepped onto the field, the Eagles took the field against the Central Michigan Chippewas and walked away from this one with a loss by a score of 24-13. The Eastern Michigan Eagles ran the ball 29 times and recorded 123 yds, which is an average of 4.2 yds per attempt. Once the final whistle blew, they ran 57 plays which gave them 298 yards. Eastern Michigan relinquished 15 completions on 19 attempts for a total of 140 yds, and a completion rate of 78.9%. Against the run, the Eagles gave up 305 yards on 51 tries, which is an average of 6.0 yards per run surrendered.

The Eagles currently have 1,870 total yards for this campaign. When it comes to getting the ball in the endzone, Eastern Michigan has earned 5 passing touchdowns and 8 rushing touchdowns. They have surrendered the football 3 different times. Eastern Michigan has accumulated 100 first downs as a unit, and they have been called for 26 penalties for 239 yds. As a team they are averaging 140.4 yards on the ground ranking them 92nd in Division 1. Regarding getting in the endzone, the Eastern Michigan Eagles are averaging 24.0 points per game.

The Eagles rank 129th in the nation regarding the opposition scoring, conceding 36.6 PPG. They are giving up an average of 6.5 yards per rush and 278.8 yards on the ground per game on the campaign. Overall, they have given up 1,394 yards via the running game in 5 contests. Concerning passing yards, the Eagles have conceded 1,079 yards which ranks them 92nd in the nation. They are giving up 215.8 yards per game via the pass as well as giving up a completion percentage of 64.3%. In total, they are conceding 494.6 yards per outing which puts them 134th in college football. They have conceded 8 touchdowns through the air as well as 15 touchdowns via the ground game.

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The Bulls come into this matchup with a record of 2-3 for this year. The last time they took the gridiron, the Bulls took a loss by a final score of 20-17 when they played the Connecticut Huskies. The Bulls finished with 329 yds on 71 plays (4.6 yards per play). Buffalo ran for 4.9 yds per carry, finishing with 204 yds on 42 attempts. Buffalo conceded 31 run attempts for 165 yards (5.3 yds per carry). The Bulls secondary gave up a completion rate of 59.4%, surrendering 155 yards on 19 out of 32 through the air.

When it comes to how much they score, the Bulls rank 91st in college football scoring 24.0 points per contest. The Buffalo Bulls average 342.4 yards per outing, ranking them 106th in the nation. The Buffalo offense has compiled 171 yards of penalties on 20 violations, which is 108th in the nation in terms of helping out the other team. They have tossed 3 picks while letting opponents recover 2 fumbles and they have obtained 94 first downs. For the season thus far, the Bulls currently have a total of 836 passing yards in addition to holding an average of 167.2 passing yards per contest, which has them ranked 113th in Division 1. They are averaging 175.2 rushing yards per game and have toted the ball for 876 yards in total.

The Bulls are conceding 19.6 PPG, which puts them 45th in Division 1. Buffalo has yielded a total of 629 yards via the ground game (125.8 yards/game) in addition to 6 touchdowns rushing on the campaign. They have allowed the opposition 6 touchdowns from the passing game and 208.2 yards/game, which has them in 65th in D-1. The Bulls defense has participated in 354 plays, which is 127th in Division 1. Their defense has earned 3 fumbles recovered and 2 interceptions this year. This year, they have conceded 98 total points.

Who will win tonight's Eagles/Bulls college football game against the spread?

Guy's Pick: Take the Bulls -10.0

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