Florida State Seminoles vs Stanford Cardinal Prediction, 10/18/2025 College Football Picks, Best Bets & Odds

Game: Florida State Seminoles vs Stanford Cardinal

Date: Saturday, October 18, 2025

Location: Stanford Stadium in Stanford, CA

TV: ESPN

Odds/Point Spread: Cardinal (+17.5)

Total/Over-Under: 54.5

The Florida State Seminoles (3-3) are on their way to Stanford Stadium on Saturday, October 18, 2025 where they will try to defeat the Stanford Cardinal (2-4). Stanford opens as 17.5-point underdogs from Vegas oddsmakers. The total is 54.5.

The Florida State Seminoles step onto the field holding a record of 3-3 for this season. The last time they stepped onto the field, the Seminoles faced the Pittsburgh Panthers and went home with a loss by a final score of 34-31. When all was said and done, they had 63 plays for 415 yards. The Florida State Seminoles ended up rushing 40 different times and recorded 170 yards, earning them an average of 4.3 yards per tote. When it came to stopping the run, the Seminoles gave up 155 yards on 42 attempts, which is an average of 3.7 yards per rush allowed. Florida State allowed 21 pass completions on 29 tries for a total of 321 yds, and a completion percentage of 72.4%.

The Seminoles have earned 3,219 total yards for this campaign. When it comes to getting the ball in the endzone, Florida State has totaled 14 touchdowns via the pass and 21 touchdowns via the ground. They have given the ball to the opposition 10 different times. Florida State has earned 160 first downs offensively, and they have been hurt by 30 penalties for 300 yds. Offensively they have an average of 274.5 yards on the ground ranking them 5th in the nation. Concerning putting points on the board, the Florida State Seminoles are averaging 44.2 PPG.

The Seminoles are ranked 62nd in college football when it comes to their opponents scoring, allowing 23.0 PPG. They are giving up an average of 3.2 yards per rushing attempt and 116.3 rushing yards per game for the campaign. For the season, they have allowed 698 rushing yards through 6 outings. When talking about passing yards, the Seminoles are allowing 1,300 yds which puts them in 61st in the nation. They are allowing 216.7 yards per game through the air in addition to conceding a completion percentage of 62.7%. In total, they have allowed 333.0 yards/game which ranks them 45th in the nation. They have yielded 11 touchdowns by air as well as 6 touchdowns running the ball.

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The Cardinal head into this game 2-4 this year. When they last stepped on the field, the Cardinal went home defeated by a final of 34-10 against the SMU Mustangs. Stanford gave up 24 rushing attempts for 122 yds (5.1 yards per rush). The Cardinal passing defense gave up a completion rate of 73.3%, relinquishing 247 yds on 22 out of 30 passing. The Cardinal finished the game with 353 yards on 74 plays (4.8 yards per play). Stanford rushed the ball for 2.3 yards per carry, finishing the contest with 75 yards on 33 attempts.

The Stanford Cardinal maintain an average of 333.5 yards/game, which has them sitting 108th in college football. The Stanford offense has totaled 375 yds of penalties on 42 violations, which is 41st in Division 1 in terms of helping out the other team. They maintain an average of 92.7 yards via the ground game and have run for 556 yards for the year. They have given away 4 interceptions while letting opponents recover 4 fumbles and they have tallied 109 first downs. When it comes to this team's ability to score points, the Cardinal currently sit 119th in Division 1 holding an average of 18.8 PPG. For the year to this point, the Cardinal currently have a total of 1,445 yards through the air as well as holding an average of 240.8 throwing yards per outing, putting them at 62nd in the nation.

The Cardinal are giving up 30.2 points per game, which has them ranked 115th in the country. Stanford has yielded a total of 688 yards rushing (114.7 yards per contest) and 5 touchdowns via the rush for the season. They have yielded 13 touchdowns through the air and 303.7 yards/game, which has them in 134th in college football. The Cardinal defense has participated in 399 plays, which ranks 70th in Division 1. Their defense has totaled 4 fumbles recovered and 1 picks on the season. In total, they have relinquished 181 points in total.

Who will win tonight's Seminoles/Cardinal college football game against the spread?

Tony's Pick: Take the Cardinal +17.5

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