Florida State Seminoles vs Virginia Cavaliers Prediction, 9/26/2025 College Football Picks, Best Bets & Odds

Game: Florida State Seminoles vs Virginia Cavaliers

Date: Friday, September 26, 2025

Location: Scott Stadium in Charlottesville, VA

TV: ESPN

Odds/Point Spread: Cavaliers (+7.5)

Total/Over-Under: 58

Scott Stadium is the location where the Virginia Cavaliers (3-1) will attempt to defeat the Florida State Seminoles (3-0) on Friday, September 26, 2025. Virginia opens this matchup as 7.5-point underdogs from oddsmakers. The betting total comes in at 58.

The Florida State Seminoles come into this game with a record of 3-0 for this year. In their last contest, the Seminoles stepped onto the field against the Kent State Golden Flashes and took home the win by a score of 66-10. On the day, they tallied 78 plays for 775 yards. The Florida State Seminoles ran the football 54 times and accounted for 498 yds, which earned them an average of 9.2 yards per carry. Against the rush, the Seminoles gave up 43 yds on 28 attempts, which averages out to 1.5 yds per rush surrendered. Florida State gave up 13 completions on 27 attempts for a total of 163 yards, and a completion percentage of 48.1%.

When it comes to putting the ball in the endzone, the Florida State Seminoles are averaging 58.0 points per game. As a team they average 363.0 yards via the ground game giving them a rank of 2nd in college football. The Seminoles have racked up 1,886 total yards for the year. When it comes to scoring, Florida State has compiled 7 touchdowns via the pass and 17 rushing touchdowns. Florida State has earned 86 first downs offensively, and they have been hurt by 12 infractions for 134 yds. They have surrendered the ball 3 times.

The Seminoles are sitting in 12th in D-1 in terms of team defense, giving up 10.0 PPG. Opposing teams are running for an average of 2.5 yards per tote and 78.3 rushing yards per contest on the season. Over the course of this year, they have conceded 235 yards on the ground through 3 games. When it comes to passing yardage, the Seminoles have conceded 509 yards which has them sitting in 17th in D-1. They have yielded 169.7 yards per contest via the pass in addition to conceding a completion percentage of 51.6%. For the year, they have yielded 248.0 yards per game ranking them 21st in D-1. They have given up 3 touchdowns via the pass and 0 touchdowns running the ball.

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The Cavaliers step onto the field holding a record of 3-1 this season. When they last played, the Cavaliers got the victory with a final of 48-20 when they played the Stanford Cardinal. Virginia rushed for 4.9 yards per tote, finishing the game with 206 yds on 42 attempts. The Cavaliers finished the contest with a total of 590 yds and they ran 74 plays (8.0 yards per play). The Cavaliers pass defense gave up a completion percentage of 69.0%, surrendering 286 yards on 20 out of 29 through the air. Virginia conceded 31 rush attempts for 35 yards (1.1 yds per carry).

The Virginia Cavaliers average 564.5 yards per game, which is good for 5th in the nation. The Virginia offense has 160 penalty yds on 22 infractions, which is good for 71st in Division 1 in terms of making mistakes. They maintain an average of 251.5 run yards per game and have run for 1,006 yards for this year. They have tossed 2 picks and they have been able to earn 106 first downs. When looking at the points being put on the board, the Cavaliers rank 11th in D-1 with an average of 45.5 PPG. For the year so far, the Cavaliers have compiled 1,252 yards through the air in addition to an average of 313.0 passing yards per contest, which has them sitting 20th in the country.

Virginia has conceded a total of 401 yards on the ground (100.3 yards/game) and 7 touchdowns via the rush so far this year. They have allowed 4 touchdowns through the air in addition to 213.3 yards per contest, which has them sitting 73rd in D-1. Over the course of the season, they have allowed 78 points. They have earned 3 fumbles recovered and 1 pick this season. The Cavaliers defense has participated in 234 plays, which is 50th in the nation. The Cavaliers are giving up 19.5 points per game, ranking them 48th in Division 1.

Who will win tonight's Seminoles/Cavaliers college football game against the spread?

Guy's Pick: Take the Cavaliers +7.5

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