Illinois Fighting Illini vs Indiana Hoosiers Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: Illinois Fighting Illini vs Indiana Hoosiers

Date: Saturday, September 20, 2025

Location: Memorial Stadium in Bloomington, IN

TV: NBC

Odds/Point Spread: Hoosiers (-4.0)

Total/Over-Under: 52.5

The Illinois Fighting Illini (3-0) are hitting the road to Memorial Stadium on Saturday, September 20, 2025 where they will attempt to beat the Indiana Hoosiers (3-0). Illinois is 4.0-point dogs from Vegas oddsmakers. The total is 52.5.

The Illinois Fighting Illini come into this game with a record of 3-0 this year. In their last matchup, the Fighting Illini played against the Western Michigan Broncos and took home the win by a score of 38-0. When the final whistle blew, they tallied 63 plays which totaled 358 yards. The Illinois Fighting Illini ended up running the ball 37 times and tallied 162 yds, which is an average of 4.4 yds per carry. In the running game, the Fighting Illini conceded 113 yards on 34 attempts, which averages out to 3.3 yds per run allowed. Illinois gave up 13 pass completions on 24 tries for a total of 91 yards, and a completion rate of 54.2%.

When talking about scoring, the Illinois Fighting Illini are sitting at 45.0 PPG. Offensively they're averaging 164.7 yards rushing ranking them 70th in college football. The Fighting Illini have earned 1,217 yards in total over the course of this season. When it comes to notching touchdowns, Illinois has compiled 8 touchdowns via the pass and 9 rushing touchdowns. Illinois has compiled 66 first downs, and they have been hurt by 17 penalties for 157 yards. They haven't turned the ball over yet.

The Fighting Illini rank 5th in D-1 concerning team defense, conceding 7.3 points per game. They are giving up an average of 2.6 yards per run and 74.0 rushing yards per game for the campaign. In total, they have allowed 222 yards via the ground game in 3 games. Concerning yards through the air, the Fighting Illini have given up 581 yards which has them sitting in 63rd in D-1. They have conceded 193.7 yards per game through the air in addition to allowing a completion percentage of 56.4%. Over the course of this season, they have relinquished 267.7 yards per outing putting them at 29th in the nation. They have surrendered 2 touchdowns by air and 0 touchdowns on the ground.

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The Hoosiers head into this matchup 3-0 this season. In their last game, the Hoosiers got the win with a final of 73-0 when they played the Indiana State Sycamores. Indiana ran the football for 8.1 yards per carry, finishing with 301 yds on 37 carries. The Hoosiers finished the contest with a total of 680 yds and they ran 67 plays (10.1 yards per play). The Hoosiers pass defense allowed a completion rate of 55.0%, surrendering 38 yds on 11 out of 20 through the air. Indiana relinquished 31 run attempts for 39 yards (1.3 yards per rush).

In relation to the points being put on the board, the Hoosiers rank 7th in college football scoring 52.0 points per outing. The Indiana Hoosiers average 591.7 yards per game, which is good for 3rd in the country. The Indiana offense has accrued 110 yds of penalties on 13 infractions, which has them ranked 106th in Division 1 in terms of hurting your team. They have earned 91 first downs. During this campaign to this point, the Hoosiers currently sit at 852 yards through the air in addition to an average of 284.0 passing yards per contest, which has them ranked 28th in Division 1. They average 307.7 rushing yards per game and have run for 923 yards for the year.

Indiana has allowed a total of 346 yards on the ground (115.3 yards per game) in addition to 2 touchdowns on the ground this year. They have surrendered 0 touchdowns from the passing game as well as 105.3 yards/contest, which has them sitting 6th in D-1. This season, they have surrendered 23 pts. They have 1 fumble and 4 interceptions on the season. The Hoosiers defense has been on the field for 149 plays, which is 20th in the nation. The Hoosiers are relinquishing 7.7 points per game, which has them ranked 6th in the nation.

Who will win tonight's Fighting Illini/Hoosiers college football game against the spread?

Guy's Pick: Take the Hoosiers -4.0

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