Illinois Fighting Illini vs Purdue Boilermakers Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Illinois Fighting Illini vs Purdue Boilermakers

Date: Saturday, October 4, 2025

Location: Ross-Ade Stadium in West Lafayette, IN

TV: BTN

Odds/Point Spread: Boilermakers (+8.5)

Total/Over-Under: 55.5

Ross-Ade Stadium is the site where the Purdue Boilermakers (2-2) will play the Illinois Fighting Illini (4-1) on Saturday, October 4, 2025. Purdue opens this matchup as 8.5-point dogs from oddsmakers. The total is set at 55.5.

The Illinois Fighting Illini head into this matchup 4-1 for this season. In their last contest, the Fighting Illini went up against the USC Trojans and earned the victory with a final of 34-32. In the game, they ran 62 plays for 502 yds. The Illinois Fighting Illini ran the football 35 times and accrued 171 yds, which earned them an average of 4.9 yds per carry. Against the rush, the Fighting Illini conceded 126 yards on 34 attempts, which is an average of 3.7 yards per run surrendered. Illinois gave up 30 completions on 43 attempts for a total of 364 yards, and a completion rate of 69.8%.

When talking about getting in the endzone, the Illinois Fighting Illini have an average of 35.8 PPG. As a unit they average 133.4 yards rushing which ranks them 101st in the nation. The Fighting Illini have earned 1,880 total yards this season. When it comes to scoring, Illinois has amassed 12 touchdowns through the air and 10 rushing touchdowns. Illinois has earned 100 first downs as an offense, and they have been called for 26 infractions for 222 yards. They have turned the football over 3 different times.

The Fighting Illini sit in 70th in D-1 concerning the opposition scoring, allowing 23.4 points per contest. They are allowing 4.0 yards per tote and 132.0 rushing yards per contest on the year. Overall, they have conceded 660 rushing yards through 5 games. When it comes to passing yards, the Fighting Illini are giving up 1,212 yds which has them sitting in 118th in D-1. They have yielded 242.4 yards per game through the air in addition to allowing a completion percentage of 65.2%. During the season, they have given up 374.4 yards/game which puts them 82nd in the nation. They have relinquished 9 touchdowns via the pass as well as 5 touchdowns running the ball.

Get all of our College Football Picks Today

The Boilermakers step onto the field holding a record of 2-2 for this year. The last time they took the field, the Boilermakers took a loss by a final score of 56-30 when they faced the Notre Dame Fighting Irish. Purdue rushed the ball for 2.4 yards per carry, totaling 66 yds on 28 carries. The Boilermakers finished with a total of 369 yards while running 68 plays (5.4 yards per play). The Boilermakers secondary gave up a completion percentage of 85.0%, surrendering 281 yards on 17 out of 20 passing. Purdue relinquished 43 running attempts for 254 yds (5.9 yds per carry).

The Purdue Boilermakers have an average of 385.8 yards per outing, which is good for 74th in the nation. The Purdue offense has accrued 190 penalty yards on 17 violations, which has them sitting 124th in the nation in terms of making mistakes. They average 106.3 yards via the ground game and have toted the ball for 425 yards for the season. They have thrown 6 interceptions while allowing opponents to recover no fumbles and they have been able to record 95 first downs. Regarding this team's ability to score points, the Boilermakers currently sit 78th in the country with an average of 28.0 PPG. For the year thus far, the Boilermakers currently sit at 1,118 passing yards along with an average of 279.5 passing yards per game, which ranks 28th in Division 1.

The Boilermakers are surrendering 26.5 points per game, which puts them 89th in D-1. Purdue has allowed a total of 629 yards rushing (157.3 yards per contest) as well as 8 touchdowns on the ground so far this year. They have allowed the opposition 3 touchdowns from the passing game and 213.0 yards per outing, which has them sitting 70th in D-1. The Boilermakers defense has taken part in 243 plays, which is 18th in the nation. They have earned 1 fumble and no picks this year. Overall, they have relinquished 106 points in total.

Who will win tonight's Fighting Illini/Boilermakers college football game against the spread?

Josh's Pick: Take the Boilermakers +8.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here