Indiana Hoosiers vs Penn State Nittany Lions Prediction, 11/8/2025 College Football Picks, Best Bets & Odds

Game: Indiana Hoosiers vs Penn State Nittany Lions

Date: Saturday, November 8, 2025

Location: Beaver Stadium in University Park, PA

TV: FOX

Odds/Point Spread: Nittany Lions (+14.5)

Total/Over-Under: 49

The Indiana Hoosiers (9-0) are headed to Beaver Stadium on Saturday, November 8, 2025 where they will take on the Penn State Nittany Lions (3-5). Indiana is 14.5-point favorites from Vegas oddsmakers. The total is 49.

The Indiana Hoosiers head into this matchup 9-0 for this season. The last time they took the field, the Hoosiers played against the Maryland Terrapins and went home with a win by a final score of 55-10. At the end of the game, they ran 75 plays which gave them a total of 588 yards. The Indiana Hoosiers ran the football 52 times and had 367 yards, which earned them an average of 7.1 yards per carry. Against the rush, the Hoosiers gave up 37 yds on 17 tries, which calculates to 2.2 yds per run allowed. Indiana conceded 18 completions on 33 attempts for a total of 256 yards, and a completion percentage of 54.5%.

When it comes to putting the ball in the endzone, the Indiana Hoosiers have an average of 46.4 points per outing. As a unit they hold an average of 245.7 yards rushing ranking this team at 6th in Division 1. The Hoosiers have tallied 4,544 total yards for the year. In terms of getting in the endzone, Indiana has earned 29 passing touchdowns and 22 rushing touchdowns. Indiana has 242 first downs offensively, and they have been hurt by 36 infractions for 275 yds. They have given the ball to the opposition 6 times.

The Hoosiers sit in 3rd in college football concerning the opposition scoring, allowing 10.8 points per game. They are allowing teams to run for an average of 3.1 yards per run and 80.0 rushing yards per contest so far this year. Over the course of this year, they have conceded 720 rushing yards through 9 games. When talking about passing yards, the Hoosiers are allowing 1,515 yards which puts them in 22nd in the nation. They have relinquished 168.3 yards per game via the pass as well as conceding a completion percentage of 60.4%. Over the course of this season, they are allowing 248.3 yards per outing which has them ranked 7th in college football. They have yielded 4 touchdowns via the pass and 3 touchdowns pounding the rock.

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The Nittany Lions come into this game with a record of 3-5 for this season. The last time they took the field, the Nittany Lions took a loss by a final score of 38-14 against the Ohio State Buckeyes. Penn State gave up 32 running attempts for 164 yards (5.1 yards per rush). The Nittany Lions secondary conceded a completion rate of 87.0%, surrendering 316 yards on 20 for 23 through the air. The Nittany Lions finished the contest with 200 yds on 60 plays (3.3 yds per play). Penn State rushed for 1.8 yards per carry, finishing with a total of 55 yds on 31 carries.

The Penn State Nittany Lions are averaging 335.6 yards per contest, which ranks them 107th in the nation. The Penn State offense has compiled 249 penalty yards on 29 infractions, which ranks them 134th in D-1 in terms of helping out the other team. They are averaging 155.3 yards per game via the rush and have run for 1,242 yards for the season. They have tossed 6 picks while losing 2 fumbles and they have obtained 156 first downs. When looking at their ability to score points, the Nittany Lions are 50th in the nation scoring 31.5 points per game. During the season so far, the Nittany Lions have compiled 1,443 passing yards together with an average of 180.4 throwing yards per contest, which ranks 114th in college football.

Penn State has yielded a total of 1,275 yards rushing (159.4 yards/game) in addition to 9 touchdowns by way of the ground game for the season. They have conceded 12 touchdowns via the pass and 166.4 yards/contest, which has them sitting 14th in college football. Overall, they have conceded 174 points. They have 5 fumbles recovered and 5 interceptions on the campaign. The Nittany Lions defense has been on the field for 514 plays, which ranks 22nd in the country. The Nittany Lions are surrendering 21.8 points per game, ranking them 41st in D-1.

Who will win tonight's Hoosiers/Nittany Lions college football game against the spread?

Tony's Pick: Take the Nittany Lions +14.5

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