Indiana Hoosiers vs Purdue Boilermakers Prediction, 11/28/2025 College Football Picks, Best Bets & Odds

Game: Indiana Hoosiers vs Purdue Boilermakers

Date: Friday, November 28, 2025

Location: Ross-Ade Stadium in West Lafayette, IN

TV: NBC Peacock

Odds/Point Spread: Boilermakers (+28.5)

Total/Over-Under: 54

The Indiana Hoosiers (11-0) are en route to Ross-Ade Stadium on Friday, November 28, 2025 where they will try to defeat the Purdue Boilermakers (2-9). Purdue opens this matchup as 28.5-point underdogs. The betting total is set at 54.

The Indiana Hoosiers come into this matchup with a record of 11-0 for this year. The last time they took the field, the Hoosiers faced the Wisconsin Badgers and went home with a win by a final score of 31-7. The Indiana Hoosiers ended up rushing 37 different times and accrued 83 yds, which had them averaging 2.2 yds per carry. In the game, they had 62 plays which converted into 388 yards. Indiana gave up 9 pass completions on 15 attempts for a total of 98 yds, and a completion rate of 60.0%. Against the run, the Hoosiers conceded 70 yds on 30 tries, which is an average of 2.3 yds per rush surrendered.

The Hoosiers have earned 5,258 total yards for the season. With reference to scoring touchdowns, Indiana has earned 34 passing touchdowns and 24 rushing touchdowns. They have turned the ball over 7 different times. Indiana has amassed 281 1st downs as a unit, and they have committed 42 penalties for 306 yards. As a team they average 218.4 yards on the ground which is 14th in Division 1. Regarding getting in the endzone, the Indiana Hoosiers have an average of 43.3 points per outing.

The Hoosiers rank 3rd in the nation concerning team defense, giving up 11.6 PPG. Opposing teams are running for an average of 3.1 yards per rush on the ground and 82.5 rushing yards per contest for the campaign. During the season, they have allowed 908 rushing yards through 11 games. Regarding passing yardage, the Hoosiers are giving up 1,832 yds which has them ranked 14th in D-1. They have surrendered 166.5 yards per contest via the pass in addition to giving up a completion percentage of 61.7%. Overall, they are conceding 249.0 yards per contest ranking them 4th in D-1. They have allowed 6 touchdowns by air as well as 6 touchdowns via the ground game.

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The Boilermakers come into this game with a record of 2-9 for this year. The last time they took the gridiron, the Boilermakers went home defeated by a final of 49-13 when they played the Washington Huskies. Purdue rushed for 3.3 yds per carry, finishing the contest with 100 yards on 30 attempts. The Boilermakers finished the game with a total of 267 yds while running 64 plays (4.2 yds per play). The Boilermakers pass defense gave up a completion rate of 81.8%, surrendering 303 yds on 27 for 33 through the air. Purdue gave up 43 rush attempts for 170 yards (4.0 yds per rush).

When it comes to their scoring prowess, the Boilermakers sit 118th in the country with an average of 20.2 points per outing. The Purdue Boilermakers are averaging 348.3 yards per outing, which has them ranked 96th in Division 1. The Purdue offense has accrued 527 yds of penalties on 55 infractions, which is 111th in college football in terms of hurting your team. They have given away 12 interceptions while letting opponents recover 7 fumbles and they have tallied 215 1st downs. During this campaign thus far, the Boilermakers currently sit at 2,368 passing yards along with an average of 215.3 passing yards per game, ranking them 82nd in D-1. They hold an average of 133.0 rushing yards per game and have toted the ball for 1,463 yards for the season.

The Boilermakers are allowing 29.6 points per game, which has them sitting 104th in college football. Purdue has conceded a total of 1,827 yards rushing (166.1 yards per contest) and 24 touchdowns by way of the ground game so far this year. They have given up 12 touchdowns through the air in addition to 246.1 yards per outing, which has them in 109th in the nation. The Boilermakers defense has participated in 719 plays, which is 51st in the nation. Their defense has tallied 6 fumbles recovered and 4 picks over the course of the season. This year, they have conceded 326 total points.

Who will win tonight's Hoosiers/Boilermakers college football game against the spread?

Tony's Pick: Take the Boilermakers +28.5

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