Iowa State Cyclones vs Arkansas State Red Wolves Prediction, 9/13/2025 College Football Picks, Best Bets & Odds

Game: Iowa State Cyclones vs Arkansas State Red Wolves

Date: Saturday, September 13, 2025

Location: Centennial Bank Stadium in Jonesboro, AR

TV: ESPN/ESPN+

Odds/Point Spread: Red Wolves (+20.5)

Total/Over-Under: 55.5

The Arkansas State Red Wolves (1-1) will play the Iowa State Cyclones (3-0) at Centennial Bank Stadium on Saturday, September 13, 2025. Iowa State is 20.5-point favorites. The total is 55.5.

The Iowa State Cyclones step onto the field holding a record of 3-0 for this season. In their last game, the Cyclones stepped onto the field against the Iowa Hawkeyes and went home with a win by a final score of 16-13. The Iowa State Cyclones ran the rock 30 times and compiled 104 yds, which earned them an average of 3.5 yards per attempt. On the day, they tallied 57 plays which gave them 238 yards. Iowa State surrendered 13 completions on 24 tries for 83 yds, and a completion rate of 54.2%. Against the run, the Cyclones conceded 131 yds on 39 tries, which calculates to 3.4 yds per run allowed.

The Cyclones have earned 1,080 total yards for the season. When it comes to scoring touchdowns, Iowa State has earned 6 touchdowns via the pass and 5 touchdowns on the ground. They have surrendered the football 3 different times. Iowa State has a total of 61 first downs as a team, and they have been called for 9 penalties for 77 yards. As a unit they hold an average of 152.3 yards on the ground ranking them 82nd in D-1. Regarding putting points on the board, the Iowa State Cyclones are averaging 31.7 points per outing.

Concerning yards via the pass, the Cyclones are allowing 482 yards which has them ranked 98th in the nation. They have yielded 160.7 yards per game via the pass and giving up a completion percentage of 58.8%. Over the course of this year, they are granting 268.7 yards per game putting them 39th in D-1. They have allowed 3 touchdowns by air and 2 touchdowns via the ground game. They are allowing teams to run for an average of 3.7 yards per tote and 108.0 yards on the ground per contest this year. In total, they have given up 324 rushing yards through 3 contests. The Cyclones are sitting in 44th in the country regarding the opposition scoring, allowing 13.7 points per game.

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The Red Wolves head into this matchup 1-1 this season. In their last game, the Red Wolves took a loss by a score of 56-14 when they played the Arkansas Razorbacks. The Red Wolves finished the contest with 285 yds while running 78 plays (3.7 yards per play). Arkansas State ran for 3.6 yds per attempt, finishing the contest with 153 yds on 42 carries. Arkansas State surrendered 29 run attempts for 321 yds (11.1 yards per rush). The Red Wolves pass defense conceded a completion rate of 69.0%, surrendering 309 yds on 20 out of 29 through the air.

Concerning the points being put on the board, the Red Wolves rank 70th in college football maintaining an average of 28.0 points per game. The Arkansas State Red Wolves are averaging 388.5 yards/game, which is good for 74th in the country. The Arkansas State offense has 126 penalty yds on 13 violations, which ranks 51st in college football in terms of helping out the other team. They have been able to earn 48 first downs. For the season thus far, the Red Wolves currently sit at 477 yards through the air as well as holding an average of 238.5 throwing yards per contest, which ranks 61st in Division 1. They hold an average of 150.0 rushing yards per game and have rushed for 300 yards in total.

Arkansas State has conceded a total of 413 yards on the ground (206.5 yards per contest) as well as 5 touchdowns on the ground this year. They have allowed the opposition 6 touchdowns through the air in addition to 290.5 yards/outing, which has them ranked 125th in D-1. They have tallied 1 fumble and 2 picks over the course of the season. The Red Wolves defense has been on the field for 127 plays, which ranks 63rd in Division 1. The Red Wolves are conceding 40.0 PPG, which has them sitting 129th in the country.

Who will win tonight's Cyclones/Red Wolves college football game against the spread?

Josh's Pick: Take the Cyclones -20.5

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