Iowa State Cyclones vs Cincinnati Bearcats Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Iowa State Cyclones vs Cincinnati Bearcats

Date: Saturday, October 4, 2025

Location: Nippert Stadium in Cincinnati, OH

TV: ESPN2

Odds/Point Spread: Bearcats (+1.0)

Total/Over-Under: 52

The Cincinnati Bearcats (3-1) host the Iowa State Cyclones (5-0) at Nippert Stadium on Saturday, October 4, 2025. Cincinnati opens this contest as 1.0-point underdogs from oddsmakers. The over/under comes in at 52.

The Iowa State Cyclones come into this matchup with a record of 5-0 for this season. In their last matchup, the Cyclones played the Arizona Wildcats and earned the victory with a final of 39-14. The Iowa State Cyclones ended up running the ball 47 different times and totaled 111 yds, which came out to an average of 2.4 yds per attempt. When the final whistle blew, they tallied 69 plays which totaled 399 yds. Iowa State gave up 32 completions on 48 attempts for 253 yds, and a completion percentage of 66.7%. In the running game, the Cyclones gave up 107 yards on 24 tries, which is 4.5 yards per run surrendered.

The Cyclones have earned 1,931 total yards for the year. When it comes to scoring touchdowns, Iowa State has earned 7 passing touchdowns and 12 rushing touchdowns. They have turned the football over 5 times. Iowa State has amassed 100 first downs, and they have committed 13 penalties for 113 yds. As a team they hold an average of 151.0 yards on the ground which is 79th in the country. In terms of putting the ball in the endzone, the Iowa State Cyclones are averaging 31.6 points per outing.

The Cyclones sit in 18th in D-1 in terms of their opponents scoring, giving up 14.2 PPG. They are allowing 3.9 yards per tote and 118.2 rushing yards per game on the season. For the year, they have given up 591 running yards through 5 games. When talking about passing yardage, the Cyclones are giving up 957 yds which has them sitting in 67th in D-1. They have surrendered 191.4 yards per outing via the pass as well as giving up a completion percentage of 61.0%. During the season, they have surrendered 309.6 yards/outing ranking them 36th in college football. They have surrendered 5 touchdowns via the pass and 3 touchdowns via the ground game.

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The Bearcats step onto the field holding a record of 3-1 for this season. When they last stepped on the gridiron, the Bearcats walked away with a victory by a final of 37-34 when they faced the Kansas Jayhawks. The Bearcats finished the game with a total of 603 yds while running 81 plays (7.4 yds per play). Cincinnati ended up running for 5.8 yds per attempt, finishing with 215 yards on 37 attempts. Cincinnati surrendered 27 running attempts for 152 yards (5.6 yards per carry). The Bearcats passing defense gave up a completion rate of 67.9%, surrendering 445 yards on 19 out of 28 through the air.

The Cincinnati Bearcats are averaging 479.5 yards per game, which is good for 17th in the country. The Cincinnati offense has accrued 205 yds of penalties on 24 violations, which is good for 92nd in D-1 in terms of helping out the opposition. They maintain an average of 191.5 yards per game via the ground game and have run for 766 yards overall. They have thrown 1 interception while allowing opponents to recover 2 fumbles and they have tallied 90 first downs. In terms of how much they score, the Bearcats sit 16th in the country averaging 39.5 points per outing. During this campaign thus far, the Bearcats currently sit at 1,152 passing yards as well as holding an average of 288.0 passing yards per outing, which ranks 25th in D-1.

Cincinnati has allowed a total of 428 yards via the ground game (107.0 yards per game) and 1 touchdown via the rush for the season. They have surrendered 7 touchdowns via the pass and 249.0 yards/outing, ranking them 105th in college football. Over the course of the season, they have surrendered 74 points in total. They have compiled 2 fumbles recovered and no picks for the year. The Bearcats defense has taken part in 255 plays, which is good for 27th in D-1. The Bearcats are relinquishing 18.5 PPG, which puts them 36th in D-1.

Who will win tonight's Cyclones/Bearcats college football game against the spread?

Guy's Pick: Take the Cyclones -1.0

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